| Great River Medical Center | Health Care and Social Assistance | $2,914,850 | $2,949,180 | 278 | N/A |  Research |
| Stracener Brothersw Construction Corporation | Construction | $1,387,500 | $1,395,478 | 110 | $125.3M | Research |
| Stracener Brothres Construction Corporation Inc. | Construction | $1,371,170 | $1,380,006 | 100 | $113.9M | Research |
| Temps Plus Inc. | Administrative and Support and Waste Management | $1,052,500 | $1,058,354 | 154 | $24.2M | Research |
| Temps Plus, Inc. | Administrative and Support and Waste Management | $1,050,000 | $1,059,062 | 141 | $22.2M | Research |
| D & L Incorporated | Construction | $957,607 | $963,113 | 114 | $36.1M | Research |
| Arkansas Mechanical LLC | Manufacturing | $894,672 | $899,869 | 60 | $14.7M | Research |
| Arkansas Mechanical LLC | Construction | $738,372 | $743,274 | 42 | $13.4M | Research |
| Ellis Processing and Material Handling Marine, LLC | Transportation and Warehousing | $650,917 | $654,587 | 40 | $10.1M | Research |
| Rickie Ellis | Transportation and Warehousing | $650,917 | $654,967 | 39 | <$5M | Research |
| Arkansas Northeastern Scrap Processing | Manufacturing | $551,140 | $554,401 | 39 | $10.2M | Research |
| Industrial Mill Services, Inc. | Manufacturing | $533,739 | $537,416 | 38 | $9.9M | Research |
| Dawson Employment Service Inc. | Administrative and Support and Waste Management | $452,000 | $454,180 | 494 | $77.7M | Research |
| Chc Heritage Square Nursing Center, LLC | Health Care and Social Assistance | $435,374 | $439,835 | 91 | $14.7M | Research |
| Legacy Mill Services, LLC | Manufacturing | $403,500 | $406,246 | 38 | $9.9M | Research |
| Dever Industrial Maintenance Solutions, LLC | Construction | $363,113 | $365,180 | 28 | $9.2M | Research |
| Nuark Warehouse & Logistics LLC | Manufacturing | $335,550 | $337,535 | 42 | $10.3M | Research |
| Jrs Concrete INC | Construction | $332,094 | $334,225 | 50 | $57.0M | Research |
| Cannon Ford of Blytheville, LLC | Retail Trade | $276,500 | $278,197 | 30 | $7.6M | Research |
| Smith-House INC | Accommodation and Food Services | $255,777 | $256,920 | 38 | $11.9M | Research |
| Houseworth Restaurants INC | Accommodation and Food Services | $248,941 | $250,200 | 43 | $7.6M | Research |
| Delta Cartage LLC | Transportation and Warehousing | $231,398 | $233,191 | 19 | <$5M | Research |
| Farmers First Gin Company | Agriculture, Forestry, Fishing and Hunting | $229,022 | $230,173 | 11 | <$5M | Research |
| Thomas & Speight, P a | Professional, Scientific, and Technical Services | $214,043 | $215,297 | 15 | <$5M | Research |
| Family Medicine Associates of Blytheville PA | Health Care and Social Assistance | $213,055 | $214,256 | 34 | $7.9M | Research |