| South Mississippi County (smc) Regional Medical Center | Health Care and Social Assistance | $761,570 | $766,161 | 68 | N/A |  Research |
| Chc Harris Healthcare, LLC | Health Care and Social Assistance | $447,300 | $452,619 | 110 | $18.7M | Research |
| Northeast Arkansas Laborforce, LLC | Construction | $339,200 | $342,462 | 50 | $11.6M | Research |
| Northeast Arkansas Laborforce LLC | Construction | $318,405 | $321,144 | 50 | $11.6M | Research |
| 3m Planting Company Gp | Agriculture, Forestry, Fishing and Hunting | $213,338 | $215,709 | 25 | <$5M | Research |
| Holthouse Farms General Partnership | Agriculture, Forestry, Fishing and Hunting | $191,805 | $193,457 | 19 | <$5M | Research |
| Mississippi County Child Development Center, Inc. | Health Care and Social Assistance | $160,000 | $161,070 | 34 | $5.5M | Research |
| Victoria Partnership | Agriculture, Forestry, Fishing and Hunting | $140,005 | $140,929 | 16 | <$5M | Research |
| Thomas & Speight, P a | Professional, Scientific, and Technical Services | $136,756 | $137,576 | 9 | <$5M | Research |
| Harshman Rentals, LLC | Retail Trade | $134,700 | $135,615 | 21 | <$5M | Research |
| The Pill Peddler Pharmacy, LLC | Retail Trade | $132,500 | $133,641 | 10 | <$5M | Research |
| H & W Wire Corp | Manufacturing | $118,485 | $119,150 | 10 | <$5M | Research |
| H & W Wire Corporation | Manufacturing | $114,427 | $0 | 17 | <$5M | Research |
| Farmers Farms | Agriculture, Forestry, Fishing and Hunting | $110,502 | $111,279 | 13 | <$5M | Research |
| Bugmobile of Arkansas, Inc. | Administrative and Support and Waste Management | $105,695 | $106,764 | 18 | <$5M | Research |
| The Pill Peddler Pharmacy LLC | Retail Trade | $102,484 | $103,827 | 12 | <$5M | Research |
| Farmers Farms | Agriculture, Forestry, Fishing and Hunting | $97,631 | $98,192 | 11 | <$5M | Research |
| Glenmar Enterprises Corporation | Accommodation and Food Services | $93,037 | $93,911 | 18 | <$5M | Research |
| Mcminn Contracting LLC | Construction | $83,135 | $83,553 | 12 | $13.7M | Research |
| 3m Planting Company, G.p. | Agriculture, Forestry, Fishing and Hunting | $81,900 | $82,746 | 7 | <$5M | Research |
| Kearney Cinema LLC | Information | $79,473 | $80,281 | 37 | $6.2M | Research |
| Lafonce Latham | Other Services (except Public Administration) | $74,496 | $75,146 | 10 | <$5M | Research |
| Kp Warren Farms | Agriculture, Forestry, Fishing and Hunting | $73,175 | $73,896 | 5 | <$5M | Research |
| Glenmar Enterprises Corporation | Accommodation and Food Services | $71,000 | $71,461 | 5 | <$5M | Research |
| Fountain Plumbing Co | Construction | $67,415 | $67,973 | 8 | <$5M | Research |