| Southern Care, Inc. | Health Care and Social Assistance | $110,020 | $111,093 | 13 | <$5M |  Research |
| Lighthouse Retail Inc. | Retail Trade | $109,193 | $109,963 | 17 | $5.2M | Research |
| Anyway Computer Co. Inc. | Professional, Scientific, and Technical Services | $106,298 | $107,487 | 12 | <$5M | Research |
| Pop's Grill, LLC | Accommodation and Food Services | $105,300 | $106,631 | 41 | $7.3M | Research |
| Wynne Baptist Church | Other Services (except Public Administration) | $100,000 | $100,544 | 35 | N/A | Research |
| Stricklin Plumbing Inc. | Construction | $98,769 | $99,678 | 10 | <$5M | Research |
| Johnson's Fish House & Diner Inc. | Accommodation and Food Services | $98,000 | $98,526 | 21 | <$5M | Research |
| Runsick Flying Service, Inc. | Agriculture, Forestry, Fishing and Hunting | $97,510 | $98,335 | 11 | <$5M | Research |
| Runsick Flying Services Inc. | Agriculture, Forestry, Fishing and Hunting | $97,294 | $97,721 | 11 | <$5M | Research |
| Anyway Computer Co. | Professional, Scientific, and Technical Services | $96,900 | $97,917 | 14 | <$5M | Research |
| Childers and Jackson Family Eye Care Inc. | Health Care and Social Assistance | $96,000 | $96,723 | 8 | <$5M | Research |
| Hicks Brothers Welding LLC | Manufacturing | $95,558 | $95,903 | 18 | <$5M | Research |
| Hicks Brothers Welding, LLC | Construction | $95,558 | $96,189 | 16 | $5.5M | Research |
| Witcher Farms Inc. | Wholesale Trade | $90,500 | $91,226 | 9 | <$5M | Research |
| Childers and Jackson Family Eye Care Inc. | Health Care and Social Assistance | $90,000 | $90,740 | 8 | <$5M | Research |
| Eab of Russellville, LLC | Information | $90,000 | $90,656 | 14 | <$5M | Research |
| Eab of Russellville LLC | Information | $90,000 | $90,325 | 14 | <$5M | Research |
| Wynne Medical Pharmacy of Cross County, Inc. | Retail Trade | $88,063 | $88,554 | 10 | <$5M | Research |
| Miss Polly's Day Care Center | Health Care and Social Assistance | $84,993 | $85,580 | 15 | N/A | Research |
| Miss Polly's Day Care Center | Health Care and Social Assistance | $84,993 | $85,481 | 14 | N/A | Research |
| Danny Voyles Farms | Agriculture, Forestry, Fishing and Hunting | $84,050 | $84,400 | 10 | <$5M | Research |
| Wynne Apothecary, Inc. | Retail Trade | $83,510 | $84,025 | 8 | <$5M | Research |
| Mary Ann Weatherford, Dds, PA | Health Care and Social Assistance | $83,000 | $83,855 | 11 | <$5M | Research |
| Mary Ann Weatherford, Dds, PA | Health Care and Social Assistance | $83,000 | $83,314 | 11 | <$5M | Research |
| Lighthouse Retail | Retail Trade | $81,893 | $82,859 | 22 | $6.7M | Research |