| Agro Pack LLC | Agriculture, Forestry, Fishing and Hunting | $2,000,000 | $2,025,111 | 499 | $25.1M |  Research |
| Jose L. Leon LLC | Accommodation and Food Services | $921,200 | $932,911 | 62 | $11.0M | Research |
| Richard L Jones Calexico INC | Transportation and Warehousing | $730,840 | $745,977 | 116 | $44.9M | Research |
| Coppell Corporation | Wholesale Trade | $668,000 | $0 | 96 | $29.4M | Research |
| Frontier Agricultural Service, Inc. | Agriculture, Forestry, Fishing and Hunting | $457,715 | $418,899 | 13 | <$5M | Research |
| Pastor of Our Lady of Guadalupe Parish Calexico | Other Services (except Public Administration) | $421,000 | $424,910 | 56 | N/A | Research |
| Our Lady of Guadalupe Catholic Parish Calexico in Calexico C | Other Services (except Public Administration) | $414,647 | $419,162 | 29 | N/A | Research |
| Econcentro, LP | Retail Trade | $375,000 | $288,433 | 80 | $16.5M | Research |
| Nsdl Corporation, Inc. | Accommodation and Food Services | $354,900 | $359,412 | 87 | $15.4M | Research |
| Leovy Perez | Agriculture, Forestry, Fishing and Hunting | $350,000 | $352,934 | 96 | <$5M | Research |
| Campillo Food Services Inc. | Accommodation and Food Services | $348,468 | $352,107 | 50 | $8.9M | Research |
| Calexico Forwarding of California, Inc. | Transportation and Warehousing | $300,415 | $303,444 | 34 | $13.2M | Research |
| Brundy Farms, Inc. | Agriculture, Forestry, Fishing and Hunting | $297,840 | $299,015 | 30 | <$5M | Research |
| Rl Jones Customs Broker of Texas LLC | Transportation and Warehousing | $279,974 | $284,070 | 82 | $31.8M | Research |
| Little Caesasr of the Valley INC | Accommodation and Food Services | $268,020 | $269,518 | 18 | <$5M | Research |
| California Super Market | Retail Trade | $263,400 | $264,425 | 71 | $17.7M | Research |
| Campillo Food Services, Inc. | Accommodation and Food Services | $260,310 | $74,011 | 49 | $8.7M | Research |
| S & S Harvest INC | Agriculture, Forestry, Fishing and Hunting | $224,434 | $227,779 | 450 | $46.0M | Research |
| El Sol Meat Market | Retail Trade | $222,615 | $224,631 | 44 | <$5M | Research |
| Hs Cars Company INC | Retail Trade | $220,266 | $223,851 | 25 | $6.3M | Research |
| Hs Cars Company INC | Retail Trade | $212,857 | $215,388 | 25 | $6.3M | Research |
| Bill Polkinhorn, Inc. | Transportation and Warehousing | $210,670 | $213,104 | 22 | $8.5M | Research |
| Garlan's Inc. | Retail Trade | $188,225 | $190,719 | 30 | $9.1M | Research |
| Francisco E Ruiz | Public Administration | $187,500 | $189,276 | 28 | N/A | Research |
| Francisco E. Ruiz | Agriculture, Forestry, Fishing and Hunting | $187,500 | $189,120 | 29 | <$5M | Research |