| Byrd Harvest, INC | Agriculture, Forestry, Fishing and Hunting | $1,694,295 | $1,710,077 | 250 | $12.6M | AI Deep Dive |
| Papalote INC | Accommodation and Food Services | $347,775 | $351,910 | 51 | $9.1M | AI Deep Dive |
| Truspro Structural Components INC | Manufacturing | $316,792 | $320,233 | 1 | <$5M | AI Deep Dive |
| Clays Septic & Jetting INC | Administrative and Support and Waste Management | $259,713 | $263,061 | 15 | <$5M | AI Deep Dive |
| Clay's Septic & Jetting, Inc. | Administrative and Support and Waste Management | $256,615 | $258,738 | 20 | <$5M | AI Deep Dive |
| Guadalupe Hardware Company, Inc. | Retail Trade | $124,007 | $125,164 | 15 | <$5M | AI Deep Dive |
| Santa Fe Nursery, Inc. | Retail Trade | $100,000 | $100,886 | 9 | <$5M | AI Deep Dive |
| Industrial Sales Co | Construction | $62,207 | $60,491 | 10 | $11.4M | AI Deep Dive |
| Pfg Guadalupe INC | Retail Trade | $60,900 | $61,531 | 10 | <$5M | AI Deep Dive |
| Pfg Guadalupe INC | Retail Trade | $60,900 | $61,299 | 10 | <$5M | AI Deep Dive |
| Jose Alvarez | Real Estate and Rental and Leasing | $54,000 | $54,497 | 5 | <$5M | AI Deep Dive |
| Star Pharmacy Rx Inc. | Retail Trade | $48,123 | $48,566 | 4 | <$5M | AI Deep Dive |
| Star Pharmacy Rx Inc. | Retail Trade | $48,123 | $48,699 | 4 | <$5M | AI Deep Dive |
| Gillaspy Steel, LLC | Manufacturing | $43,250 | $43,782 | 9 | <$5M | AI Deep Dive |
| Golden State Recovery INC | Administrative and Support and Waste Management | $42,750 | $42,890 | 3 | <$5M | AI Deep Dive |
| No Limit Tire, Inc. | Professional, Scientific, and Technical Services | $38,700 | $39,118 | 4 | <$5M | AI Deep Dive |
| Rosa Quiroga | Accommodation and Food Services | $38,510 | $38,651 | 5 | <$5M | AI Deep Dive |
| Guadalupe-Nipomo Dunes Center | Arts, Entertainment, and Recreation | $36,466 | $36,674 | 2 | N/A | AI Deep Dive |
| Guadalupe-Nipomo Dunes Center | Arts, Entertainment, and Recreation | $36,465 | $36,818 | 4 | N/A | AI Deep Dive |
| Our Lady of Guadalupe Catholic Church | Other Services (except Public Administration) | $34,580 | $34,961 | 1 | <$5M | AI Deep Dive |
| Our Lady of Guadalupe Catholic Church | Other Services (except Public Administration) | $32,900 | $33,046 | 6 | <$5M | AI Deep Dive |
| Smc Business Services INC | Professional, Scientific, and Technical Services | $25,535 | $25,739 | 4 | <$5M | AI Deep Dive |
| Vivanco Trucking Inc. | Transportation and Warehousing | $20,833 | $20,930 | 1 | <$5M | AI Deep Dive |
| Noriz Trucking | Unknown | $20,833 | $21,108 | 1 | N/A | AI Deep Dive |
| Filemon Meza | Administrative and Support and Waste Management | $20,833 | $20,883 | 1 | <$5M | AI Deep Dive |