| Santa Cruz Seaside Company | Arts, Entertainment, and Recreation | $6,236,226 | $6,287,995 | 243 | $34.0M |  Research |
| Rector, Wardens, Vestry of Calvary Church, a Non-Profit | Other Services (except Public Administration) | $4,968,837 | $39,987 | 6 | N/A | Research |
| Encompass Community Services | Health Care and Social Assistance | $4,786,545 | $4,563,247 | 450 | N/A | Research |
| New Teacher Center | Public Administration | $3,071,357 | $3,123,360 | 133 | N/A | Research |
| Nhs, INC | Wholesale Trade | $2,133,000 | $2,156,726 | 134 | $41.0M | Research |
| Santa Cruz Community Health Centers | Health Care and Social Assistance | $2,056,422 | $2,079,916 | 151 | N/A | Research |
| Santa Cruz Medical Group | Health Care and Social Assistance | $2,047,277 | $2,069,937 | 99 | $19.6M | Research |
| Verve, LLC | Manufacturing | $2,025,475 | $2,051,886 | 246 | $86.8M | Research |
| Ecology Action of Santa Cruz | Professional, Scientific, and Technical Services | $2,000,000 | $2,012,333 | 107 | N/A | Research |
| Santa Cruz Seaside Company | Arts, Entertainment, and Recreation | $2,000,000 | $2,010,521 | 215 | $30.1M | Research |
| Verve LLC | Retail Trade | $1,962,522 | $1,992,440 | 184 | $20.4M | Research |
| Ecology Action of Santa Cruz | Professional, Scientific, and Technical Services | $1,878,900 | $1,893,618 | 110 | N/A | Research |
| Ontera Inc. | Professional, Scientific, and Technical Services | $1,753,630 | $1,768,097 | 89 | $18.5M | Research |
| Sea Eagle Lp. | Accommodation and Food Services | $1,717,410 | $1,739,854 | 164 | $29.1M | Research |
| Ontera Inc. | Professional, Scientific, and Technical Services | $1,610,727 | $1,642,677 | 36 | $7.5M | Research |
| Ccof Certification Services LLC | Professional, Scientific, and Technical Services | $1,304,840 | $1,318,889 | 77 | $10.8M | Research |
| Fullpower Technologies, Inc. | Professional, Scientific, and Technical Services | $1,304,070 | $940,027 | 58 | $12.1M | Research |
| Janus of Santa Cruz | Health Care and Social Assistance | $1,268,927 | $1,282,312 | 149 | N/A | Research |
| Janus of Santa Cruz | Health Care and Social Assistance | $1,266,820 | $1,282,577 | 123 | N/A | Research |
| Bpr Properties Ucsc LLC | Accommodation and Food Services | $1,256,300 | $1,095,332 | 118 | $36.9M | Research |
| Beauty Solutions, LLC | Wholesale Trade | $1,165,000 | $1,179,779 | 91 | $27.9M | Research |
| Sea Eagle, LP | Accommodation and Food Services | $1,160,382 | $1,174,720 | 202 | $35.9M | Research |
| Santa Cruz Skilled Nursing Center Inc. | Health Care and Social Assistance | $1,155,090 | $1,162,542 | 132 | $26.2M | Research |
| Canyon View Properties, INC | Real Estate and Rental and Leasing | $1,116,467 | $967,507 | 113 | $13.2M | Research |
| Dientes Community Dental | Health Care and Social Assistance | $1,116,075 | $1,128,887 | 70 | N/A | Research |