| West Central, Inc. | Health Care and Social Assistance | $1,970,357 | $1,985,310 | 132 | $23.5M |  Research |
| Developmental Opportunities, Inc. | Health Care and Social Assistance | $1,918,462 | $1,951,289 | 220 | N/A | Research |
| Tezak Heavy Equipment Co., Inc. | Construction | $1,477,731 | $1,491,901 | 87 | $27.0M | Research |
| Fremont Paving and Redi Mix, Inc. | Manufacturing | $889,811 | $895,867 | 99 | $98.2M | Research |
| Echo Canyon River Expeditions LLC | Accommodation and Food Services | $880,706 | $884,229 | 22 | $6.9M | Research |
| A & S Construction LLC | Construction | $879,573 | $885,622 | 78 | $24.2M | Research |
| Canon City & Royal Gorge Railroad LLC | Transportation and Warehousing | $781,263 | $785,408 | 179 | $45.4M | Research |
| Canon City and Royal Gorge Railroad, LLC | Transportation and Warehousing | $781,200 | $789,728 | 32 | $12.3M | Research |
| Cornella Brothers Inc. | Construction | $524,241 | $529,862 | 62 | $19.2M | Research |
| New Horizons Ministries INC | Retail Trade | $489,554 | $492,062 | 33 | $6.3M | Research |
| Royal Gorge Company of Colorado | Arts, Entertainment, and Recreation | $482,200 | $749,992 | 28 | <$5M | Research |
| The Bill Berry Motor Company | Retail Trade | $456,060 | $459,594 | 37 | $9.3M | Research |
| Hildebrand Homecare Inc. | Health Care and Social Assistance | $435,397 | $438,409 | 147 | $25.2M | Research |
| Fbf, LLC | Retail Trade | $419,737 | $422,698 | 37 | $9.3M | Research |
| Gateway to Success PC | Health Care and Social Assistance | $358,212 | $360,621 | 24 | <$5M | Research |
| Button Family Practice, P.c. | Health Care and Social Assistance | $343,200 | $347,441 | 38 | $11.9M | Research |
| Royal Gorge Rafting Inc. | Arts, Entertainment, and Recreation | $337,475 | $338,982 | 38 | $5.3M | Research |
| Brady Brothers Inc. | Retail Trade | $314,802 | $316,536 | 21 | <$5M | Research |
| White Water Bar & Grill Inc. | Accommodation and Food Services | $289,869 | $291,426 | 34 | $6.0M | Research |
| Echo Canyon River Expeditions, LLC | Arts, Entertainment, and Recreation | $289,500 | $572,186 | 20 | <$5M | Research |
| Ary Brothers Trucking INC | Construction | $287,921 | $289,917 | 30 | $9.3M | Research |
| Lindner Chevrolet INC | Retail Trade | $265,011 | $267,792 | 31 | $7.8M | Research |
| Dfc Ceramics, LLC | Manufacturing | $258,200 | $260,669 | 27 | $26.8M | Research |
| Royal Gorge Zip Line Tours Inc. | Arts, Entertainment, and Recreation | $252,590 | $253,960 | 27 | <$5M | Research |
| Howard Disposal Service LLC | Real Estate and Rental and Leasing | $251,485 | $252,835 | 17 | $7.7M | Research |