| Jjnj INC | Accommodation and Food Services | $2,333,000 | $2,360,485 | 376 | $66.8M |  Research |
| Glenwood Hot Springs Lodge & Pool | Accommodation and Food Services | $1,958,963 | $1,974,152 | 161 | $50.3M | Research |
| Schmueser Gordon Meyer, Inc. | Professional, Scientific, and Technical Services | $1,892,200 | $906,590 | 116 | $14.3M | Research |
| Mountain Family Health Centers | Other Services (except Public Administration) | $1,500,000 | $1,513,890 | 146 | N/A | Research |
| Glenwood Hot Springs Lodge & Pool | Accommodation and Food Services | $1,404,500 | $1,413,678 | 150 | $46.9M | Research |
| Mountain Valley Development Services INC | Health Care and Social Assistance | $1,275,000 | $1,284,292 | 190 | N/A | Research |
| Gould Construction, Inc. | Construction | $1,247,900 | $1,256,185 | 83 | $25.7M | Research |
| Glenwood Medical Associates | Health Care and Social Assistance | $1,197,643 | $1,204,205 | 90 | $28.2M | Research |
| R&a Enterprises of Carbondale, Inc. | Construction | $1,087,900 | $1,095,202 | 102 | $33.6M | Research |
| R&a Enterprises of Carbondale INC | Construction | $1,003,400 | $1,011,455 | 100 | $32.9M | Research |
| Berthod Motors, Inc. | Retail Trade | $969,075 | $978,443 | 76 | $19.2M | Research |
| Glenwood Medical Associates | Health Care and Social Assistance | $912,500 | $917,700 | 96 | $30.1M | Research |
| Bighorn Motors INC | Retail Trade | $875,600 | $885,939 | 62 | $15.6M | Research |
| Historic Hotel Colorado, LLC | Accommodation and Food Services | $845,123 | $848,410 | 72 | $22.5M | Research |
| Glenwood Tramway LLC | Arts, Entertainment, and Recreation | $831,600 | $836,253 | 67 | $9.4M | Research |
| Rms Concrete Inc. | Construction | $707,500 | $712,495 | 43 | $9.9M | Research |
| Rms Concrete INC | Construction | $704,135 | $708,784 | 43 | $9.9M | Research |
| Glenwood Springs Ford INC | Retail Trade | $665,200 | $669,064 | 54 | $13.6M | Research |
| Gia Group, LLC | Finance and Insurance | $634,100 | $640,493 | 42 | $21.6M | Research |
| Historic Hotel Colorado, LLC | Accommodation and Food Services | $625,500 | $731,667 | 44 | $13.8M | Research |
| Young Services LLC | Construction | $599,279 | $602,592 | 47 | $14.9M | Research |
| Glenwood Canyon Brewing Co LLC | Accommodation and Food Services | $590,643 | $597,976 | 55 | $9.8M | Research |
| Glenwood Springs Subaru, Inc. | Retail Trade | $565,600 | $541,675 | 42 | $10.6M | Research |
| Integrity Pizza, LLC | Accommodation and Food Services | $559,700 | $630,826 | 139 | $24.7M | Research |
| Decypher Technologies Inc. | Professional, Scientific, and Technical Services | $540,989 | $545,213 | 26 | $5.4M | Research |