| Prowers County Hospital District | Health Care and Social Assistance | $2,896,900 | $2,929,973 | 195 | $38.7M |  Research |
| High Plains Community Health Center INC | Health Care and Social Assistance | $1,249,078 | $1,262,991 | 84 | $16.7M | Research |
| High Plains Community Health Center Incorporated | Health Care and Social Assistance | $1,233,565 | $1,243,845 | 130 | $23.1M | Research |
| Colorado Mills, LLC | Manufacturing | $470,445 | $474,993 | 45 | $15.9M | Research |
| Prowers Co Bd for Handicapped | Health Care and Social Assistance | $345,500 | $347,506 | 63 | $10.2M | Research |
| Lamar Estates LLC | Health Care and Social Assistance | $345,004 | $348,700 | 57 | $9.7M | Research |
| Arkansas Valley Diesel Service, INC | Real Estate and Rental and Leasing | $315,220 | $68,109 | 8 | <$5M | Research |
| Semco Incorporated | Manufacturing | $271,510 | $273,463 | 41 | $10.7M | Research |
| Semco INC | Utilities | $269,693 | $271,701 | 18 | N/A | Research |
| Heath & Son & Turpin Trucking, INC | Transportation and Warehousing | $240,335 | $242,638 | 17 | <$5M | Research |
| Heath & Son & Turpin Trucking Inc. | Transportation and Warehousing | $240,334 | $241,476 | 17 | <$5M | Research |
| Ports to Plains Travel Plaza | Retail Trade | $200,680 | $202,542 | 44 | $14.7M | Research |
| Who Manufacturing Co INC | Manufacturing | $188,048 | $190,232 | 13 | <$5M | Research |
| Tri County Ford Lincoln Mercury INC | Retail Trade | $184,527 | $185,680 | 22 | $5.5M | Research |
| Charley Taylor | Construction | $157,760 | $158,707 | 14 | <$5M | Research |
| Taylor Septic and Plumbing | Construction | $157,760 | $159,535 | 14 | <$5M | Research |
| G Pelley INC | Retail Trade | $155,709 | $157,724 | 11 | <$5M | Research |
| Lamar Area Hospice Association | Health Care and Social Assistance | $152,800 | $153,725 | 30 | $5.1M | Research |
| Tri County Ford Lincoln INC | Retail Trade | $152,722 | $153,744 | 22 | $5.5M | Research |
| Bj's Burger & Beverage | Accommodation and Food Services | $137,038 | $138,043 | 34 | $6.0M | Research |
| Wallace Gas and Oil Inc. | Wholesale Trade | $132,038 | $132,485 | 14 | <$5M | Research |
| Wallace Gas & Oil, Inc. | Wholesale Trade | $130,500 | $131,482 | 14 | <$5M | Research |
| Lamar Building Material Supplies | Retail Trade | $127,046 | $128,101 | 19 | <$5M | Research |
| Elite Oil Feild Services, Inc. | Mining, Quarrying, and Oil and Gas Extraction | $122,968 | $124,851 | 8 | <$5M | Research |
| Air Care INC | Agriculture, Forestry, Fishing and Hunting | $116,537 | $121,649 | 10 | <$5M | Research |