| Connecticut Orthopaedic Specialists, P.c. | Health Care and Social Assistance | $7,117,098 | $7,204,480 | 500 | $156.9M |  Research |
| The Children's Center of Hamden | Health Care and Social Assistance | $2,316,100 | $2,344,655 | 230 | N/A | Research |
| The Hamden Hall School, Inc. | Educational Services | $2,267,200 | $2,300,866 | 170 | N/A | Research |
| Whitney Center, Incorporated | Health Care and Social Assistance | $2,250,000 | $2,277,555 | 272 | N/A | Research |
| Transact Technologies Incorporated | Professional, Scientific, and Technical Services | $2,172,800 | $2,198,100 | 118 | $24.4M | Research |
| Whitney Manor Operating Company, LLC | Health Care and Social Assistance | $1,644,684 | $1,665,366 | 188 | $32.0M | Research |
| Whitehawk Construction Services, Inc. | Construction | $1,576,204 | $1,593,367 | 55 | $18.7M | Research |
| Burt Process Equipment Inc. | Wholesale Trade | $1,309,200 | $1,320,570 | 110 | $33.7M | Research |
| Hamden Rehabilitation LLC | Health Care and Social Assistance | $1,307,624 | $1,324,928 | 158 | $26.9M | Research |
| Simione Healthcare Consultants LLC | Health Care and Social Assistance | $1,230,030 | $1,234,984 | 60 | $10.9M | Research |
| Simione Healthcare Consultants LLC | Professional, Scientific, and Technical Services | $1,230,030 | $1,239,634 | 60 | $6.2M | Research |
| Mechanical Plumbing & Heating | Construction | $1,221,800 | $1,229,599 | 78 | $24.7M | Research |
| Sam Malone Brewing Company INC | Accommodation and Food Services | $1,147,825 | $1,157,951 | 76 | $13.5M | Research |
| Leed Himmel Industries INC | Manufacturing | $1,111,650 | $1,117,345 | 86 | $21.0M | Research |
| Leed Himmel Industries INC | Manufacturing | $1,101,650 | $1,106,479 | 78 | $19.1M | Research |
| Hoffmann Architects, Inc. | Professional, Scientific, and Technical Services | $981,312 | $990,910 | 44 | $13.6M | Research |
| Hoffmann Architects, Inc. | Professional, Scientific, and Technical Services | $980,569 | $991,181 | 42 | $13.0M | Research |
| Mcr Property Management INC | Real Estate and Rental and Leasing | $980,100 | $991,056 | 125 | $18.1M | Research |
| Visiting Nurse Services, Inc. of Southern Connecticut | Health Care and Social Assistance | $934,275 | $944,949 | 58 | $9.9M | Research |
| Visiting Nurse Services Inc. of Souther | Health Care and Social Assistance | $934,275 | $943,567 | 58 | $9.9M | Research |
| Community Social Integration LLC | Health Care and Social Assistance | $884,807 | $895,134 | 152 | $24.6M | Research |
| Kramden Enterprises INC | Accommodation and Food Services | $880,572 | $886,820 | 102 | $18.1M | Research |
| Eye Center of Southern Connecticut, P.c. | Health Care and Social Assistance | $842,900 | $847,888 | 58 | $18.2M | Research |
| Sm Malone Brewing Company, INC | Arts, Entertainment, and Recreation | $819,875 | $826,097 | 76 | $12.5M | Research |
| American Total Protection LLC | Other Services (except Public Administration) | $787,500 | $793,390 | 65 | $12.4M | Research |