| American Cedar & Millwork, Inc. | Retail Trade | $1,244,008 | $1,258,322 | 83 | $17.1M |  Research |
| Delaware Anesthesia Associates PA | Health Care and Social Assistance | $1,139,900 | $895,320 | 22 | $6.9M | Research |
| Sea Haven Home Care LLC | Health Care and Social Assistance | $954,700 | $965,476 | 205 | $35.1M | Research |
| Sussex Emergency Associates | Professional, Scientific, and Technical Services | $771,057 | $775,726 | 34 | <$5M | Research |
| George Sherman Corporation | Construction | $753,249 | $760,510 | 59 | $18.7M | Research |
| George Sherman Corporation | Construction | $753,249 | $759,170 | 54 | $17.1M | Research |
| Savannah Animal Hospital, LLC | Professional, Scientific, and Technical Services | $752,700 | $761,444 | 83 | $11.6M | Research |
| Crooked Hammock Brewpubs LLC | Accommodation and Food Services | $722,865 | $731,282 | 83 | $14.7M | Research |
| I.g. Burton of Lewes LLC | Retail Trade | $714,700 | $723,241 | 55 | $13.9M | Research |
| Harvard Business Services, Inc. | Administrative and Support and Waste Management | $673,043 | $676,694 | 40 | $7.6M | Research |
| Mid-Atlantic Family Practice, LLC | Health Care and Social Assistance | $642,735 | $651,628 | 47 | $14.8M | Research |
| Atlantic Refrigeration and Air Conditioning INC | Construction | $599,169 | $602,544 | 54 | $17.1M | Research |
| The Dental Group at Carpenter's Crossing LLC | Health Care and Social Assistance | $576,615 | $584,324 | 44 | $10.2M | Research |
| The Dental Group at Carpenter's Crossing LLC | Health Care and Social Assistance | $575,155 | $579,993 | 40 | $9.3M | Research |
| Grassroots Team LLC | Administrative and Support and Waste Management | $555,421 | $559,834 | 190 | $35.9M | Research |
| Mfc Lewes De LLC | Accommodation and Food Services | $494,928 | $497,979 | 64 | $11.4M | Research |
| Lewes Pigs LLC | Accommodation and Food Services | $473,823 | $478,808 | 51 | $9.1M | Research |
| Big Oyster LLC | Accommodation and Food Services | $453,383 | $455,990 | 48 | $8.5M | Research |
| Greenleaf Services, Inc. | Administrative and Support and Waste Management | $451,729 | $439,223 | 49 | $10.6M | Research |
| Cape Gazzette Ltd | Information | $442,190 | $445,631 | 19 | <$5M | Research |
| Summit Orthopaedic Home Care LLC | Health Care and Social Assistance | $431,492 | $436,754 | 50 | $8.6M | Research |
| Summit Orthopaedic Home Care LLC | Health Care and Social Assistance | $431,492 | $436,202 | 50 | $8.6M | Research |
| Kms Industries INC | Real Estate and Rental and Leasing | $423,195 | $87,282 | 29 | <$5M | Research |
| Southern Delaware Imaging Associates LLC | Health Care and Social Assistance | $418,169 | $420,900 | 20 | <$5M | Research |
| Cardiovascular Consultants of Southern Delaware LLC | Health Care and Social Assistance | $399,700 | $404,041 | 36 | $11.3M | Research |