| Hendry County Hospital Authority | Health Care and Social Assistance | $2,945,700 | $2,980,476 | 277 | N/A |  Research |
| Rouge River Farms Inc. | Agriculture, Forestry, Fishing and Hunting | $1,890,250 | $1,912,460 | 381 | $38.9M | Research |
| Clewiston Nursing & Rehabilitation LLC | Health Care and Social Assistance | $1,096,400 | $1,111,449 | 139 | $23.6M | Research |
| C & B Farms INC | Agriculture, Forestry, Fishing and Hunting | $1,022,400 | $1,028,250 | 176 | $18.0M | Research |
| Three G Trucking, INC | Agriculture, Forestry, Fishing and Hunting | $463,200 | $468,501 | 200 | $10.0M | Research |
| Clyde Johnson Contracting & Roofing Inc. | Construction | $400,700 | $405,030 | 87 | $26.4M | Research |
| Clewiston Christian School INC | Educational Services | $366,400 | $368,710 | 42 | N/A | Research |
| Ridgdill & Son INC | Construction | $359,605 | $363,051 | 40 | $12.4M | Research |
| Ridgdill & Son INC | Construction | $359,600 | $361,688 | 26 | $8.1M | Research |
| D & J Machinery Inc. | Manufacturing | $289,400 | $292,037 | 26 | $6.8M | Research |
| J & J Ag Products, Inc. | Transportation and Warehousing | $280,100 | $281,944 | 37 | <$5M | Research |
| Mama Bear Lawn Care Pressure Clean LLC | Professional, Scientific, and Technical Services | $250,000 | $0 | 3 | <$5M | Research |
| Glades Media LLP | Information | $248,300 | $250,486 | 26 | <$5M | Research |
| Glades Media Company LLP | Information | $248,300 | $250,707 | 38 | $6.4M | Research |
| Rayburn Companies INC | Agriculture, Forestry, Fishing and Hunting | $200,000 | $201,803 | 28 | <$5M | Research |
| Everglades Harvest and Haul, LLC | Agriculture, Forestry, Fishing and Hunting | $200,000 | $0 | 70 | <$5M | Research |
| Quality Electric Contracting Inc. | Construction | $183,600 | $184,620 | 19 | $6.3M | Research |
| Hilliard Produce LLC | Agriculture, Forestry, Fishing and Hunting | $181,100 | $182,856 | 19 | <$5M | Research |
| Hato Potrero Farm, Inc. | Manufacturing | $177,300 | $179,408 | 38 | $13.4M | Research |
| Potts Co Industrial Services LLC | Construction | $177,215 | $178,487 | 25 | $8.5M | Research |
| Hilliard Brothers of Florida Lllp | Agriculture, Forestry, Fishing and Hunting | $176,700 | $178,025 | 19 | <$5M | Research |
| J & J Pharmacy, LLC | Retail Trade | $175,200 | $176,465 | 27 | <$5M | Research |
| Potts Co Industrial Services LLC | Construction | $173,345 | $174,746 | 28 | $9.5M | Research |
| J & J Farms, Inc. | Agriculture, Forestry, Fishing and Hunting | $168,800 | $170,108 | 12 | <$5M | Research |
| Rayburn Companies INC | Agriculture, Forestry, Fishing and Hunting | $167,172 | $168,807 | 31 | <$5M | Research |