| The Vacation Property Group, Llc. | Real Estate and Rental and Leasing | $499,460 | $504,113 | 133 | $60.1M |  Research |
| El Jalisco Mexican Restaurant Inc. | Accommodation and Food Services | $479,500 | $486,358 | 80 | $14.2M | Research |
| Collins Vacation Rentals INC | Real Estate and Rental and Leasing | $371,018 | $374,392 | 39 | $5.8M | Research |
| Barbers Seafood, INC | Wholesale Trade | $228,467 | $229,965 | 16 | <$5M | Research |
| Taylor's Building Supply, INC | Retail Trade | $188,487 | $189,576 | 13 | <$5M | Research |
| Jason White Construction , LLC | Construction | $163,565 | $165,273 | 26 | $29.6M | Research |
| Doc Myers Island Pub, LLC | Accommodation and Food Services | $158,000 | $159,437 | 19 | <$5M | Research |
| The Beach Pit Restaurant, Inc. | Accommodation and Food Services | $144,817 | $145,831 | 13 | <$5M | Research |
| Shcoia LLC | Accommodation and Food Services | $92,072 | $93,116 | 45 | $8.0M | Research |
| Coastline Clearing & Development, LLC | Construction | $90,337 | $91,082 | 12 | <$5M | Research |
| Coastline Clearing and Dev LLC | Construction | $90,335 | $90,835 | 12 | $13.7M | Research |
| Local Store INC | Retail Trade | $87,272 | $88,276 | 13 | <$5M | Research |
| Apalachicola Bay Animal Clinic LLC | Professional, Scientific, and Technical Services | $86,856 | $87,672 | 9 | <$5M | Research |
| Franklins Promise Coalition INC | Other Services (except Public Administration) | $84,858 | $85,135 | 18 | N/A | Research |
| Butler Agency LLC | Finance and Insurance | $81,065 | $81,718 | 5 | <$5M | Research |
| St George Cantina LLC | Accommodation and Food Services | $80,259 | $80,699 | 10 | <$5M | Research |
| Wefings Inc. | Retail Trade | $79,254 | $80,181 | 10 | <$5M | Research |
| Saltwater Sol Hospitality LLC | Accommodation and Food Services | $78,125 | $78,607 | 12 | <$5M | Research |
| Family Coasta Restaurant On the Bay LLC | Accommodation and Food Services | $75,000 | $45,005 | 19 | <$5M | Research |
| Family Coastal Restaurant On the Bay LLC | Accommodation and Food Services | $73,794 | $74,263 | 25 | <$5M | Research |
| Collins Construction of St. George Island INC | Construction | $73,400 | $73,899 | 8 | <$5M | Research |
| Bobby James INC | Construction | $72,867 | $73,598 | 10 | <$5M | Research |
| Alice Collins Realty, INC | Real Estate and Rental and Leasing | $58,489 | $58,877 | 6 | <$5M | Research |
| Fisher Stucco, INC | Construction | $54,532 | $55,110 | 9 | <$5M | Research |
| Pure Ventures | Unknown | $52,567 | $53,234 | 5 | N/A | Research |