| Stahl-Meyer Foods, INC | Retail Trade | $1,353,700 | $1,366,940 | 165 | $41.2M |  Research |
| Madison County Hospital Health Systems INC | Health Care and Social Assistance | $987,932 | $996,110 | 147 | N/A | Research |
| Total Air Care, INC | Construction | $875,000 | $885,428 | 44 | $13.9M | Research |
| Lake Park Operations LLC | Health Care and Social Assistance | $831,800 | $843,099 | 116 | $19.7M | Research |
| Consolidated Group of Madison INC | Health Care and Social Assistance | $631,778 | $635,534 | 100 | $17.0M | Research |
| Total Air Care INC | Construction | $625,792 | $629,204 | 44 | $13.4M | Research |
| Johnson & Johnson Transport INC | Wholesale Trade | $375,762 | $380,981 | 28 | $7.2M | Research |
| Gray Logging LLC | Agriculture, Forestry, Fishing and Hunting | $308,935 | $311,458 | 29 | <$5M | Research |
| Madison Creative Arts Academy, INC | Educational Services | $304,320 | $305,960 | 38 | N/A | Research |
| Gordon Tractor INC | Retail Trade | $260,312 | $262,467 | 27 | $7.1M | Research |
| Madison Dental Associates PA | Health Care and Social Assistance | $251,032 | $253,194 | 28 | $6.5M | Research |
| Madison Dental Associates, PA | Health Care and Social Assistance | $228,693 | $230,541 | 26 | $6.0M | Research |
| The Arc Big Bend INC | Health Care and Social Assistance | $202,152 | $204,005 | 58 | $9.4M | Research |
| Ragans Family Campground | Accommodation and Food Services | $167,900 | $168,917 | 24 | $7.5M | Research |
| James Madison Preparatory High School INC | Educational Services | $150,353 | $151,242 | 18 | N/A | Research |
| Jimmie Ragans Enterprises INC | Accommodation and Food Services | $146,800 | $147,685 | 11 | <$5M | Research |
| Mtc South Inc. | Manufacturing | $133,987 | $135,749 | 15 | <$5M | Research |
| Browning & Sons INC | Agriculture, Forestry, Fishing and Hunting | $126,546 | $127,311 | 9 | <$5M | Research |
| Jimmie's Firestone & Service Center INC | Other Services (except Public Administration) | $126,195 | $127,250 | 13 | <$5M | Research |
| Madison Veterinary Clinic, LLC | Professional, Scientific, and Technical Services | $124,307 | $125,464 | 18 | <$5M | Research |
| Ragans Family Campground | Accommodation and Food Services | $119,943 | $120,946 | 20 | $6.3M | Research |
| Genesis Timber LLC | Agriculture, Forestry, Fishing and Hunting | $118,417 | $119,104 | 7 | <$5M | Research |
| Family First Wellness Clinic LLC | Health Care and Social Assistance | $113,188 | $114,203 | 10 | <$5M | Research |
| Jimmie Ragans Enterprises INC | Accommodation and Food Services | $104,875 | $105,752 | 25 | <$5M | Research |
| Ragans Motel INC | Accommodation and Food Services | $98,400 | $98,993 | 18 | $5.6M | Research |