| Ts Lodging LLC | Accommodation and Food Services | $1,126,250 | $1,135,291 | 42 | $13.1M |  Research |
| Ts Lodging, LLC | Accommodation and Food Services | $891,600 | $902,446 | 55 | $17.2M | Research |
| Casa Ybel Resort Ptnrship - Cab1691 | Accommodation and Food Services | $839,311 | $843,381 | 77 | $24.1M | Research |
| Sanibel Packing Company, INC | Retail Trade | $835,200 | $844,480 | 116 | $23.9M | Research |
| Casa Ybel Resort Partnership | Accommodation and Food Services | $708,500 | $714,071 | 75 | $23.5M | Research |
| Portland Norwich Group LLC | Accommodation and Food Services | $698,100 | $701,377 | 57 | $17.8M | Research |
| Tutela Solutions LLC | Professional, Scientific, and Technical Services | $606,219 | $611,675 | 35 | <$5M | Research |
| Timbers of Sanibel Inc. | Accommodation and Food Services | $568,472 | $571,634 | 57 | $10.1M | Research |
| Norwich Aventura Ii, LLC | Accommodation and Food Services | $545,000 | $551,152 | 63 | $19.7M | Research |
| Portland Norwich Group, LLC | Accommodation and Food Services | $498,600 | $504,251 | 57 | $17.8M | Research |
| Sanibel-Captiva Conservation Foundation Inc. | Other Services (except Public Administration) | $426,771 | $428,314 | 32 | N/A | Research |
| Island Cow Inc. | Accommodation and Food Services | $421,008 | $422,416 | 43 | $7.6M | Research |
| Tutela Solutions LLC | Professional, Scientific, and Technical Services | $404,800 | $407,656 | 24 | <$5M | Research |
| Island Cow, Inc. | Accommodation and Food Services | $397,958 | $401,076 | 46 | $8.2M | Research |
| Norwich Aventura I LLC | Accommodation and Food Services | $389,700 | $391,605 | 50 | $15.6M | Research |
| Traders Sanibel LLC | Accommodation and Food Services | $389,283 | $390,786 | 28 | <$5M | Research |
| Mudbugs Cajun Kitchen LLC | Accommodation and Food Services | $388,598 | $391,070 | 47 | $8.3M | Research |
| Sanibel-Captiva Conservation Foundation, Inc. | Other Services (except Public Administration) | $379,246 | $381,334 | 33 | N/A | Research |
| Simar Sanibel Management, Inc. | Real Estate and Rental and Leasing | $356,700 | $361,020 | 42 | $6.3M | Research |
| Upper Valley Hotel Group LLC | Accommodation and Food Services | $344,577 | $346,434 | 30 | $9.4M | Research |
| Island Inn Company Inc. | Accommodation and Food Services | $334,040 | $335,738 | 32 | $10.0M | Research |
| Lazy Flamingo 2 INC | Accommodation and Food Services | $313,355 | $315,966 | 30 | $5.3M | Research |
| Sanibel Majik Inc. | Accommodation and Food Services | $290,583 | $292,135 | 36 | $6.4M | Research |
| Timbers of Sanibel, INC | Accommodation and Food Services | $289,677 | $292,058 | 79 | $14.0M | Research |
| Gramma Dot's Inc. | Accommodation and Food Services | $281,188 | $282,797 | 21 | <$5M | Research |