| Crystal Health and Rehab Center LLC | Health Care and Social Assistance | $745,217 | $752,545 | 83 | $14.1M |  Research |
| Adventure Environmental, INC | Professional, Scientific, and Technical Services | $488,491 | $493,858 | 19 | <$5M | Research |
| Adventure Environmental INC | Professional, Scientific, and Technical Services | $472,400 | $477,034 | 14 | <$5M | Research |
| The Hvac Store, Inc. | Retail Trade | $463,100 | $469,468 | 32 | <$5M | Research |
| Cbt Construction and Development Inc. | Construction | $444,000 | $449,513 | 45 | $51.3M | Research |
| Jeff Gautier Landscaping, Inc. | Administrative and Support and Waste Management | $435,000 | $442,310 | 22 | <$5M | Research |
| Florida Keys Ambulance Service INC | Health Care and Social Assistance | $413,087 | $419,651 | 35 | $8.1M | Research |
| Plantation Boat Mart and Marina, Inc. | Retail Trade | $398,023 | $403,671 | 26 | $6.8M | Research |
| Amy's Angels Health Care INC | Health Care and Social Assistance | $394,831 | $399,061 | 60 | $13.9M | Research |
| Regan Insurance Agency, Inc. | Finance and Insurance | $354,101 | $356,148 | 21 | $10.8M | Research |
| Florida Keys Ambulance Service, INC | Health Care and Social Assistance | $335,271 | $340,718 | 35 | $8.1M | Research |
| Florida Keys Children's Shelter Inc. | Health Care and Social Assistance | $303,199 | $304,918 | 40 | N/A | Research |
| Florida Keys Children's Shelter INC | Health Care and Social Assistance | $278,812 | $282,173 | 29 | N/A | Research |
| Hershoff, Lupino & Yagel LLP | Professional, Scientific, and Technical Services | $262,900 | $264,412 | 17 | <$5M | Research |
| Advance Mechanical Service, Inc. | Construction | $250,300 | $253,165 | 32 | $7.4M | Research |
| Plantation Boat Mart and Marina INC | Retail Trade | $239,406 | $242,279 | 21 | $5.5M | Research |
| Coral Restoration Foundation | Agriculture, Forestry, Fishing and Hunting | $227,127 | $229,411 | 17 | N/A | Research |
| Old Tavernier Corporation | Accommodation and Food Services | $219,919 | $222,069 | 31 | $5.5M | Research |
| The Coral Restoration Foundation Nc. | Public Administration | $216,270 | $217,604 | 30 | N/A | Research |
| Islamorada Pool Service & Maintenance, LLC | Administrative and Support and Waste Management | $214,825 | $216,220 | 27 | $5.8M | Research |
| Islamorada Pool Service & Maintenance Ll | Construction | $214,825 | $216,656 | 29 | $9.9M | Research |
| Jeff Gautier Landscaping INC | Administrative and Support and Waste Management | $208,750 | $211,412 | 17 | <$5M | Research |
| Law Offices Cytryn and Velazquez PA | Professional, Scientific, and Technical Services | $201,210 | $203,943 | 16 | <$5M | Research |
| Curry Dixon Construction LLC | Construction | $192,500 | $194,152 | 18 | $5.5M | Research |
| Unique Marine, INC | Retail Trade | $190,840 | $193,925 | 13 | <$5M | Research |