| Willowbrook Management, Inc. | Health Care and Social Assistance | $665,600 | $670,740 | 81 | $13.8M |  Research |
| Niemerg's Inc. | Accommodation and Food Services | $663,370 | $667,314 | 170 | $30.2M | Research |
| Family Care Associates of Effingham, S.c. | Health Care and Social Assistance | $648,242 | $651,936 | 58 | $18.2M | Research |
| Putnam Trucking Operations Company INC | Transportation and Warehousing | $640,342 | $644,095 | 45 | $9.1M | Research |
| Senior Health Specialties, Inc. | Health Care and Social Assistance | $639,690 | $643,826 | 185 | $31.5M | Research |
| Monroe Bartels, Inc. | Construction | $605,000 | $608,512 | 43 | $9.9M | Research |
| Agracel, Inc. | Real Estate and Rental and Leasing | $590,417 | $595,043 | 31 | <$5M | Research |
| St Anthony Church | Other Services (except Public Administration) | $579,737 | $584,867 | 99 | N/A | Research |
| Hetzels Overland Transport, Inc. | Transportation and Warehousing | $551,610 | $554,708 | 30 | $6.8M | Research |
| Linders Limited Ii, LLC | Accommodation and Food Services | $538,650 | $542,561 | 174 | $30.9M | Research |
| St Anthony of Padua Parish of Effingham | Other Services (except Public Administration) | $523,894 | $526,047 | 97 | N/A | Research |
| J & J Ventures Amusements, LLC | Arts, Entertainment, and Recreation | $507,838 | $510,565 | 60 | $8.4M | Research |
| Russ Braunecker Cadillac, Buick, Gmc Truck, Inc. | Retail Trade | $505,280 | $508,076 | 48 | $12.1M | Research |
| Lavender Ridge Inc. | Health Care and Social Assistance | $491,765 | $496,723 | 85 | $14.5M | Research |
| Effingham Asphalt Co | Construction | $486,240 | $489,455 | 31 | $9.6M | Research |
| Effingham Asphalt Co | Construction | $486,240 | $489,549 | 31 | $9.6M | Research |
| Bahrns Equipment, Inc. | Retail Trade | $469,557 | $472,870 | 48 | $9.9M | Research |
| Firefly Farm LLC | Accommodation and Food Services | $466,224 | $469,622 | 50 | $8.9M | Research |
| Effingham Obstetrics and Gynecology Associates LLC | Health Care and Social Assistance | $447,512 | $450,100 | 30 | $9.4M | Research |
| Pyramid Marble & Granite INC | Manufacturing | $443,730 | $447,061 | 44 | $11.5M | Research |
| Jansen Cable Construction, Inc. | Construction | $438,700 | $441,259 | 32 | $9.9M | Research |
| Roy Schmidt Motors, INC | Retail Trade | $436,007 | $441,716 | 34 | $8.6M | Research |
| Contractors Concrete, Inc. | Manufacturing | $430,940 | $433,334 | 42 | $41.7M | Research |
| Diepholz Auto Group Inc. | Retail Trade | $421,500 | $426,464 | 36 | $9.1M | Research |
| Workman Management Group, LLC | Management of Companies and Enterprises | $415,000 | $371,487 | 21 | <$5M | Research |