| Southern Orthopedic Associates, S.c. | Health Care and Social Assistance | $5,320,400 | $5,386,577 | 457 | $143.4M |  AI Deep Dive |
| Shawnee Express Inc. | Transportation and Warehousing | $912,450 | $918,939 | 81 | $12.2M | AI Deep Dive |
| Shawnee Express, Inc. | Transportation and Warehousing | $912,449 | $919,242 | 80 | $12.1M | AI Deep Dive |
| Southern Illinois Dermatology, | Health Care and Social Assistance | $761,400 | $769,369 | 104 | $32.6M | AI Deep Dive |
| Shawnee Senior Living LLC | Health Care and Social Assistance | $665,870 | $673,786 | 117 | $19.9M | AI Deep Dive |
| Ron Ward Chevrolet Company, INC | Retail Trade | $381,475 | $385,206 | 31 | $7.8M | AI Deep Dive |
| Southern Illinois Ob-Gyn Associates, S.c. | Health Care and Social Assistance | $361,000 | $363,848 | 22 | $6.9M | AI Deep Dive |
| South Side Lumber Inc. | Retail Trade | $331,700 | $334,054 | 37 | $7.6M | AI Deep Dive |
| Our Lady of Mt. Carmel Catholic Church | Other Services (except Public Administration) | $316,000 | $317,697 | 54 | N/A | AI Deep Dive |
| Our Lady of Mount Carmel Catholic Church | Other Services (except Public Administration) | $316,000 | $317,732 | 53 | N/A | AI Deep Dive |
| Williamson County Programs | Health Care and Social Assistance | $293,100 | $295,132 | 85 | N/A | AI Deep Dive |
| Sollami Company | Wholesale Trade | $279,010 | $281,418 | 27 | $8.3M | AI Deep Dive |
| Pass & Pass, LLC | Construction | $260,372 | $262,062 | 24 | $7.6M | AI Deep Dive |
| Our Directions, Inc. | Health Care and Social Assistance | $229,288 | $232,328 | 48 | $8.2M | AI Deep Dive |
| Our Directions Inc. | Retail Trade | $223,672 | $224,891 | 55 | $8.6M | AI Deep Dive |
| Natural Enrichment Industries, LLC | Retail Trade | $222,657 | $221,275 | 20 | <$5M | AI Deep Dive |
| Orthotech Sports - Medical Equipment, Inc. | Manufacturing | $220,500 | $221,746 | 15 | <$5M | AI Deep Dive |
| Orthotech Sports Medical Equipment Inc. | Arts, Entertainment, and Recreation | $220,500 | $222,062 | 18 | <$5M | AI Deep Dive |
| Southern Illinois Autos, INC | Retail Trade | $217,756 | $220,042 | 21 | $5.3M | AI Deep Dive |
| Herrin Rehabilitation and Nursing Center, LLC | Health Care and Social Assistance | $185,077 | $188,105 | 26 | <$5M | AI Deep Dive |
| Qsc Herrin, Inc. | Accommodation and Food Services | $174,147 | $175,779 | 44 | $7.8M | AI Deep Dive |
| Keren Hart, Ltd. | Wholesale Trade | $172,365 | $173,313 | 22 | $5.7M | AI Deep Dive |
| Monchino Management LLC | Accommodation and Food Services | $170,590 | $171,389 | 6 | <$5M | AI Deep Dive |
| Keren Hart, Ltd. | Retail Trade | $168,200 | $169,204 | 20 | $6.7M | AI Deep Dive |
| Incubator Supply, Inc. | Manufacturing | $160,000 | $161,771 | 16 | <$5M | AI Deep Dive |