| Mcdonough County Hospital District | Health Care and Social Assistance | $6,495,700 | $6,634,816 | 477 | N/A |  Research |
| Farm King Supply, LLC | Retail Trade | $1,197,500 | $1,206,016 | 232 | $36.2M | Research |
| Laverdiere Construction, Inc. | Construction | $996,835 | $1,002,401 | 72 | $82.0M | Research |
| Wesley Village, Inc. | Health Care and Social Assistance | $984,400 | $994,873 | 165 | N/A | Research |
| Laz Ii, INC | Accommodation and Food Services | $560,000 | $565,444 | 159 | $28.2M | Research |
| Kunes Country Auto Group of Macomb, INC | Retail Trade | $506,100 | $510,967 | 50 | $12.6M | Research |
| Mcdonough Power Cooperative | Utilities | $396,517 | $400,680 | 16 | N/A | Research |
| Jj's of Macomb, INC | Accommodation and Food Services | $350,043 | $352,737 | 112 | $19.9M | Research |
| Mabes Enterprises, Inc. | Retail Trade | $308,100 | $311,027 | 61 | $6.8M | Research |
| Woodrum Automotive INC | Retail Trade | $303,678 | $305,314 | 41 | $10.3M | Research |
| Woodrum Automotive, Inc. | Retail Trade | $292,773 | $295,571 | 28 | $5.8M | Research |
| Ymca of Mcdonough County | Arts, Entertainment, and Recreation | $272,780 | $275,129 | 143 | N/A | Research |
| Ymca of Mcdonough County | Arts, Entertainment, and Recreation | $272,780 | $274,576 | 143 | N/A | Research |
| West Side Lumber Co | Retail Trade | $253,200 | $255,366 | 23 | <$5M | Research |
| The Lamoine Assisted Living and Memory | Health Care and Social Assistance | $250,623 | $252,788 | 35 | $6.0M | Research |
| Macomb Senior Living, LLC | Health Care and Social Assistance | $232,655 | $228,832 | 46 | $7.8M | Research |
| Purdum Gray Ingledue Beck, INC | Finance and Insurance | $208,132 | $209,734 | 18 | $9.2M | Research |
| Chick N Lipps of Macomb LLC | Accommodation and Food Services | $203,689 | $205,850 | 26 | <$5M | Research |
| Purdum Gray Ingledue Beck INC | Finance and Insurance | $193,811 | $194,855 | 17 | $8.7M | Research |
| Lci Concrete INC | Manufacturing | $190,720 | $191,953 | 16 | $15.9M | Research |
| Arnold Bros. Heating & Cooling Inc. | Construction | $187,500 | $189,474 | 16 | $5.1M | Research |
| Eric Botts | Professional, Scientific, and Technical Services | $179,737 | $180,505 | 30 | $9.5M | Research |
| Western Illinois Tourism Development Inc. | Public Administration | $172,455 | $173,315 | 9 | N/A | Research |
| Chick N Lipps of Macomb, LLC | Accommodation and Food Services | $160,660 | $161,950 | 22 | <$5M | Research |
| Optometric Billing Consultants, LLC | Professional, Scientific, and Technical Services | $157,605 | $159,023 | 27 | $8.6M | Research |