| Southern Illinois Living Centers INC | Health Care and Social Assistance | $1,207,500 | $1,218,300 | 151 | $25.7M |  AI Deep Dive |
| Southern Illinois Community Support Services, INC | Health Care and Social Assistance | $347,500 | $350,608 | 45 | $7.7M | AI Deep Dive |
| Royal Living Center INC | Real Estate and Rental and Leasing | $334,711 | $336,580 | 56 | $8.4M | AI Deep Dive |
| Crown Roofing & Exteriors, Inc. | Construction | $109,090 | $110,656 | 22 | $7.3M | AI Deep Dive |
| Dcl Construction, Inc. | Construction | $106,116 | $106,971 | 12 | $13.7M | AI Deep Dive |
| Pederson Hvac INC | Construction | $95,785 | $97,349 | 11 | <$5M | AI Deep Dive |
| D7 Roofing LLC | Construction | $92,320 | $93,492 | 10 | <$5M | AI Deep Dive |
| Dr. William G. Koentz | Health Care and Social Assistance | $87,845 | $88,323 | 8 | <$5M | AI Deep Dive |
| Berkemann's Baker's Dozen | Manufacturing | $77,282 | $78,087 | 45 | $15.9M | AI Deep Dive |
| Al Noor Restaurant Corporation | Accommodation and Food Services | $75,882 | $76,793 | 31 | $5.5M | AI Deep Dive |
| A Fine Swine Barbecue I Corp | Accommodation and Food Services | $74,137 | $74,901 | 22 | <$5M | AI Deep Dive |
| Al Noor Restaurant Corporation | Accommodation and Food Services | $54,201 | $54,660 | 15 | <$5M | AI Deep Dive |
| Mascoutah Hvac, LLC | Construction | $52,812 | $53,259 | 4 | <$5M | AI Deep Dive |
| Mascoutah Hvac LLC | Construction | $52,812 | $53,015 | 4 | <$5M | AI Deep Dive |
| Rwk Building and Remodeling Co. Inc. | Construction | $52,169 | $52,579 | 5 | <$5M | AI Deep Dive |
| Rwk Building & Remodeling Co., INC | Construction | $52,169 | $52,652 | 5 | <$5M | AI Deep Dive |
| Mission Accomplished Tire and Auto, Inc. | Retail Trade | $48,600 | $48,933 | 5 | <$5M | AI Deep Dive |
| Southern Mutual Insurance Company | Finance and Insurance | $45,300 | $45,607 | 6 | <$5M | AI Deep Dive |
| Wegmann Farms | Agriculture, Forestry, Fishing and Hunting | $41,667 | $41,853 | 2 | <$5M | AI Deep Dive |
| Stan & Joe Kalmer | Agriculture, Forestry, Fishing and Hunting | $41,667 | $41,769 | 2 | <$5M | AI Deep Dive |
| Lori Thompson | Accommodation and Food Services | $39,568 | $40,491 | 13 | <$5M | AI Deep Dive |
| Johnson Veterinary Care, Inc. | Professional, Scientific, and Technical Services | $37,135 | $37,547 | 4 | <$5M | AI Deep Dive |
| El Indio De New Baden, Inc. | Accommodation and Food Services | $32,991 | $33,270 | 9 | <$5M | AI Deep Dive |
| Ahner Florist & Greenhouses | Retail Trade | $30,332 | $30,489 | 27 | $5.1M | AI Deep Dive |
| Quality Alterations Inc. | Other Services (except Public Administration) | $29,520 | $29,687 | 10 | <$5M | AI Deep Dive |