| The Horton Group, Inc. | Finance and Insurance | $6,526,600 | $6,605,826 | 369 | $189.6M |  Research |
| Elite Medical Transportation LLC | Health Care and Social Assistance | $5,607,555 | $5,720,485 | 500 | $115.9M | Research |
| John Burns Construction Company | Construction | $4,166,700 | $4,214,874 | 161 | $49.9M | Research |
| Darvin Furniture and Appliance of Orland Park, Inc. | Retail Trade | $3,294,600 | $3,334,587 | 233 | $42.2M | Research |
| Ctf Illinois | Health Care and Social Assistance | $2,942,740 | $2,977,005 | 435 | N/A | Research |
| Joe Rizza Ford of Orland Park, Inc. | Retail Trade | $2,045,619 | $2,069,371 | 126 | $31.8M | Research |
| Orland Park Imports INC | Retail Trade | $1,609,900 | $1,620,554 | 109 | $27.5M | Research |
| Egg Strategy, Inc. | Professional, Scientific, and Technical Services | $1,303,987 | $1,316,813 | 68 | $7.0M | Research |
| Zeigler Orland Park, LLC | Retail Trade | $1,282,987 | $1,297,082 | 90 | $22.7M | Research |
| Associated Urological Specialists, LLC | Health Care and Social Assistance | $1,272,026 | $1,286,085 | 147 | $46.1M | Research |
| Madison Construction Company | Construction | $1,184,402 | $1,191,768 | 38 | $9.6M | Research |
| 510 W42 Hotel Operating LLC | Accommodation and Food Services | $1,177,355 | $1,164,380 | 117 | $36.6M | Research |
| Parkview Christian Church in Orland Park | Other Services (except Public Administration) | $1,147,575 | $1,154,875 | 98 | N/A | Research |
| Parkview Christian Church in Orland Park | Other Services (except Public Administration) | $1,147,500 | $1,155,265 | 98 | N/A | Research |
| Midwest Animal Hospital, LLC | Professional, Scientific, and Technical Services | $1,126,388 | $1,134,429 | 129 | $18.1M | Research |
| Zeigler Nissan Orland Park, LLC | Retail Trade | $1,116,300 | $1,128,686 | 78 | $19.7M | Research |
| Midwest Orthopaedic Consultants, S.c. | Health Care and Social Assistance | $1,103,953 | $1,112,171 | 72 | $22.6M | Research |
| Community Imports, INC | Retail Trade | $1,088,300 | $1,094,951 | 78 | $19.7M | Research |
| Triton Plumbing, LLC | Construction | $1,072,770 | $1,085,375 | 37 | $11.7M | Research |
| Triton Plumbing LLC | Construction | $1,072,770 | $1,078,819 | 34 | $10.8M | Research |
| Associates in Sleep Medicine, LLC | Health Care and Social Assistance | $1,071,783 | $1,086,341 | 97 | $30.4M | Research |
| Associates in Sleep Medicine LLC | Health Care and Social Assistance | $1,071,782 | $1,086,906 | 93 | $29.2M | Research |
| Veristar LLC | Information | $1,047,065 | $1,057,943 | 65 | $10.9M | Research |
| Community Imports Inc. | Retail Trade | $1,028,200 | $1,035,226 | 114 | $28.7M | Research |
| Madison Construction Company | Construction | $989,910 | $1,001,328 | 38 | $9.6M | Research |