| Martin Sullivan, INC | Wholesale Trade | $3,410,800 | $3,457,604 | 251 | $76.9M | AI Deep Dive |
| Apostolic Christian Home of Roanoke Illinois, INC | Health Care and Social Assistance | $605,100 | $609,184 | 97 | N/A | AI Deep Dive |
| Roanoke Farmers Association | Wholesale Trade | $394,742 | $398,503 | 18 | <$5M | AI Deep Dive |
| Roanoke Motor Company, Inc. | Retail Trade | $297,700 | $299,782 | 26 | $6.6M | AI Deep Dive |
| Knapp Johnson Harris Funeral Home INC | Other Services (except Public Administration) | $293,000 | $296,028 | 48 | $9.2M | AI Deep Dive |
| Roanoke Autos, LLC | Retail Trade | $246,600 | $248,294 | 21 | $5.3M | AI Deep Dive |
| Gem Equipment & Manufacturing, LLC | Manufacturing | $212,900 | $215,165 | 14 | <$5M | AI Deep Dive |
| H & D Quality Builders, Inc. | Construction | $188,100 | $190,044 | 19 | $5.8M | AI Deep Dive |
| Central Illinois Carriers, Inc. | Transportation and Warehousing | $138,900 | $140,551 | 12 | <$5M | AI Deep Dive |
| Cloudpoint Geographics, Inc. | Professional, Scientific, and Technical Services | $106,300 | $107,080 | 9 | <$5M | AI Deep Dive |
| Caleri's Cafe & Bakery LLC | Accommodation and Food Services | $102,585 | $103,192 | 37 | $6.6M | AI Deep Dive |
| Michael D Meier Dmd LLC | Health Care and Social Assistance | $76,100 | $76,825 | 10 | <$5M | AI Deep Dive |
| Caleri's Cafe and Bakery LLC | Manufacturing | $73,200 | $73,893 | 39 | $13.8M | AI Deep Dive |
| Hodels, Inc. | Wholesale Trade | $69,400 | $70,125 | 9 | <$5M | AI Deep Dive |
| Steve Byrd Farms, Inc. | Agriculture, Forestry, Fishing and Hunting | $69,300 | $69,935 | 11 | <$5M | AI Deep Dive |
| Steve Byrd Farms Inc. | Agriculture, Forestry, Fishing and Hunting | $69,300 | $69,602 | 8 | <$5M | AI Deep Dive |
| Hodel Turkey Farm Inc. | Agriculture, Forestry, Fishing and Hunting | $68,900 | $69,260 | 8 | <$5M | AI Deep Dive |
| Hodel Turkey Farm, Inc. | Agriculture, Forestry, Fishing and Hunting | $68,900 | $69,488 | 12 | <$5M | AI Deep Dive |
| Sauder Furniture, Inc. | Retail Trade | $68,300 | $68,955 | 5 | <$5M | AI Deep Dive |
| Lifts of Illinois Inc. | Construction | $65,020 | $65,444 | 4 | <$5M | AI Deep Dive |
| Lifts of Illinois INC | Retail Trade | $65,000 | $65,618 | 4 | <$5M | AI Deep Dive |
| S&s Reconditioning Inc. | Other Services (except Public Administration) | $60,052 | $60,602 | 5 | <$5M | AI Deep Dive |
| Veatch Brothers Farm Services, Inc. | Construction | $55,300 | $55,838 | 7 | <$5M | AI Deep Dive |
| Nathan Wiegand | Agriculture, Forestry, Fishing and Hunting | $49,560 | $50,150 | 8 | <$5M | AI Deep Dive |
| Nathan Wiegand | Agriculture, Forestry, Fishing and Hunting | $49,560 | $49,859 | 7 | <$5M | AI Deep Dive |