| John Jones Salem Dealerships, INC | Retail Trade | $1,020,256 | $1,028,027 | 103 | $26.0M |  Research |
| Eddie Gilstrap Motors, Inc. | Retail Trade | $686,100 | $593,061 | 64 | $16.1M | Research |
| Temple & Temple Excavating & Paving, INC | Construction | $657,700 | $664,926 | 25 | $9.4M | Research |
| Peerless Gear, LLC | Manufacturing | $566,000 | $571,487 | 56 | $14.7M | Research |
| Stingel Enterprises, INC | Manufacturing | $233,715 | $171,532 | 20 | $5.6M | Research |
| T&t Pipe Renovations LLC | Construction | $182,700 | $184,412 | 25 | $8.5M | Research |
| Cottongim Enterprises INC | Construction | $158,600 | $159,626 | 15 | $17.1M | Research |
| Cottongim Enterprises INC | Construction | $149,900 | $150,949 | 16 | $18.2M | Research |
| Salem True Value, Inc. | Retail Trade | $149,600 | $157,127 | 25 | $5.2M | Research |
| Molon Labe Arms LLC | Wholesale Trade | $143,345 | $144,344 | 11 | <$5M | Research |
| Mission in Home Services and Associates LLC | Health Care and Social Assistance | $137,105 | $138,491 | 16 | <$5M | Research |
| Knapp Miller Brown Insurance Services INC | Finance and Insurance | $121,200 | $122,459 | 15 | $7.7M | Research |
| Moore's Animal Care Clinic of Salem INC | Professional, Scientific, and Technical Services | $112,797 | $114,376 | 12 | <$5M | Research |
| H & R Bakery | Retail Trade | $107,500 | $108,640 | 16 | <$5M | Research |
| Kearschner Family Dentistry LLC | Health Care and Social Assistance | $103,017 | $103,896 | 11 | <$5M | Research |
| Walker Recycling INC | Administrative and Support and Waste Management | $103,000 | $104,021 | 18 | <$5M | Research |
| Walls Lawn Care Service, Inc. | Retail Trade | $100,800 | $104,953 | 40 | $8.3M | Research |
| Mike Baker Trucker LLC | Transportation and Warehousing | $95,000 | $50,870 | 5 | <$5M | Research |
| International Wood, Inc. | Manufacturing | $93,935 | $94,710 | 5 | <$5M | Research |
| Hacker Sawmill & Trucking Inc. | Transportation and Warehousing | $92,410 | $92,718 | 10 | <$5M | Research |
| Sapphire Personal Home Service Agency LLC | Health Care and Social Assistance | $91,885 | $92,507 | 33 | $5.7M | Research |
| Hillcrest Pallet INC | Manufacturing | $91,197 | $91,954 | 17 | $16.9M | Research |
| Kearschner Family Dentistry LLC | Health Care and Social Assistance | $91,100 | $91,887 | 13 | <$5M | Research |
| Certainty Home Inspections LLC | Professional, Scientific, and Technical Services | $90,400 | $91,267 | 9 | <$5M | Research |
| Neff Family Fertilizer, Inc. | Wholesale Trade | $86,500 | $86,962 | 8 | <$5M | Research |