| Purdue Research Foundation | Other Services (except Public Administration) | $6,327,075 | $6,400,620 | 365 | N/A |  Research |
| Bioanalytical Systems, Inc. | Manufacturing | $5,051,281 | $4,910,071 | 249 | $247.0M | Research |
| Lafayette Venetian Blind INC | Manufacturing | $3,900,600 | $3,946,324 | 250 | $65.5M | Research |
| Indiana Professional Management Group, Inc. | Health Care and Social Assistance | $3,371,500 | $3,408,025 | 330 | $53.5M | Research |
| Atlas Excavating INC | Construction | $2,024,100 | $2,017,259 | 95 | $35.6M | Research |
| Westminster Village West Lafayette INC | Health Care and Social Assistance | $1,648,900 | $1,661,233 | 320 | N/A | Research |
| University Place | Health Care and Social Assistance | $728,992 | $732,920 | 65 | N/A | Research |
| Proaxis INC | Manufacturing | $648,065 | $653,392 | 53 | $13.0M | Research |
| Proaxis, Inc. | Construction | $648,000 | $653,344 | 63 | $10.8M | Research |
| Randall Dermatology, PC | Health Care and Social Assistance | $641,797 | $649,833 | 69 | $21.7M | Research |
| Winco Construction Company | Construction | $592,330 | $596,371 | 51 | $11.8M | Research |
| Purdue Alumni Association INC | Other Services (except Public Administration) | $590,420 | $594,124 | 43 | N/A | Research |
| Lafayette Tv LLC | Information | $544,300 | $548,550 | 56 | $9.4M | Research |
| Granite Management LLC | Real Estate and Rental and Leasing | $493,000 | $497,471 | 49 | $7.3M | Research |
| James Scharer Masonry INC | Construction | $485,987 | $488,623 | 36 | $10.9M | Research |
| Siteworx, LLC | Construction | $467,600 | $473,185 | 15 | <$5M | Research |
| Parsolex Gmp Center, Inc. | Manufacturing | $390,400 | $392,959 | 23 | $22.8M | Research |
| Next Generation Care Concepts, Inc. | Health Care and Social Assistance | $368,700 | $371,852 | 64 | $10.4M | Research |
| On Target Laboratories, INC | Professional, Scientific, and Technical Services | $365,985 | $370,797 | 15 | <$5M | Research |
| Parsolex Gmp Center Inc. | Manufacturing | $364,800 | $367,465 | 23 | $22.8M | Research |
| University Book Store, Inc. | Retail Trade | $356,200 | $358,208 | 60 | $14.1M | Research |
| Heman Lawson Hawks LLP | Professional, Scientific, and Technical Services | $345,800 | $350,054 | 25 | $8.0M | Research |
| Lafayette Limo INC | Transportation and Warehousing | $342,759 | $345,942 | 68 | $66.0M | Research |
| R&w Contracting, INC | Construction | $323,600 | $305,830 | 14 | <$5M | Research |
| Kjg Architecture Inc. | Professional, Scientific, and Technical Services | $321,079 | $322,996 | 31 | $9.6M | Research |