| First Cooperative Association | Agriculture, Forestry, Fishing and Hunting | $2,970,900 | $3,024,376 | 250 | $25.5M |  Research |
| Sioux Valley Memorial Hospital Association | Health Care and Social Assistance | $2,808,900 | $3,375,072 | 247 | N/A | Research |
| R.j. Thomas Manufacturing Company, INC | Manufacturing | $872,204 | $879,899 | 75 | $18.3M | Research |
| Christensen Bros., INC | Construction | $423,252 | $427,195 | 26 | $8.1M | Research |
| Mongan Painting Co, Inc. | Construction | $405,000 | $407,241 | 24 | $6.1M | Research |
| Holzhauer Motors, Ltd. | Retail Trade | $372,600 | $375,234 | 44 | $11.1M | Research |
| Holzhauer Motors, Ltd. | Retail Trade | $367,830 | $352,286 | 42 | $10.6M | Research |
| Mongan Painting Co, Inc. | Construction | $325,600 | $328,481 | 26 | $8.9M | Research |
| Schoon Corporation | Construction | $309,212 | $310,896 | 24 | $7.4M | Research |
| Foundation Analytical Laboratory INC | Professional, Scientific, and Technical Services | $307,161 | $308,611 | 27 | $5.4M | Research |
| Grundman-Hicks, L.l.c. | Construction | $287,700 | $291,184 | 13 | $14.8M | Research |
| Foundation Analytical Lab, Inc. | Other Services (except Public Administration) | $268,800 | $270,682 | 23 | <$5M | Research |
| Schoon Corporation | Construction | $221,200 | $222,662 | 33 | $12.4M | Research |
| Cmsrx., Inc. | Retail Trade | $214,485 | $216,548 | 20 | <$5M | Research |
| Haselhoff Construction, Inc. | Construction | $162,400 | $163,424 | 13 | $14.8M | Research |
| Valley Veterinary Center PC | Professional, Scientific, and Technical Services | $156,902 | $157,796 | 28 | <$5M | Research |
| Burkhardt & Dawson, INC | Professional, Scientific, and Technical Services | $151,000 | $152,615 | 11 | <$5M | Research |
| Modern Heating & Cooling Inc. | Construction | $134,847 | $136,037 | 10 | <$5M | Research |
| Schoon Construction and Excavation, LLC | Construction | $119,432 | $120,348 | 13 | <$5M | Research |
| Scherrin, Inc. | Construction | $116,700 | $117,702 | 11 | <$5M | Research |
| Holzhauer Ford Cherokee INC | Retail Trade | $114,100 | $114,841 | 10 | <$5M | Research |
| Sanitary Service, Inc. | Administrative and Support and Waste Management | $109,280 | $110,289 | 12 | <$5M | Research |
| Scherrin Inc. | Construction | $109,242 | $109,864 | 11 | <$5M | Research |
| Builders Sharpening & Service, LLC | Retail Trade | $107,600 | $108,377 | 11 | <$5M | Research |
| Herrick, Ary, Cook Cook Cook & Cook | Professional, Scientific, and Technical Services | $104,690 | $105,571 | 7 | <$5M | Research |