| Featherlite Trailer Manufacturing, LLC | Manufacturing | $3,995,600 | $4,080,063 | 249 | $65.2M |  Research |
| Regional Health Services of Howard County | Health Care and Social Assistance | $2,359,700 | $2,219,141 | 262 | N/A | Research |
| Alum-Line, Inc. | Manufacturing | $635,100 | $642,121 | 67 | $17.5M | Research |
| Plantpeddler, Inc. | Agriculture, Forestry, Fishing and Hunting | $403,524 | $335,432 | 23 | <$5M | Research |
| Evans Memorial Home for the Aged, Inc. | Health Care and Social Assistance | $363,300 | $366,550 | 39 | N/A | Research |
| Universal Freight, LLC | Transportation and Warehousing | $360,400 | $365,436 | 28 | $6.4M | Research |
| Kenneth Moellers | Agriculture, Forestry, Fishing and Hunting | $287,693 | $289,357 | 35 | $5.7M | Research |
| Kenneth C. Moellers | Agriculture, Forestry, Fishing and Hunting | $266,520 | $268,572 | 35 | $5.7M | Research |
| Paris Foods INC | Agriculture, Forestry, Fishing and Hunting | $257,087 | $258,982 | 29 | <$5M | Research |
| Camp-Site Rv, Inc. | Retail Trade | $247,649 | $249,888 | 24 | $6.3M | Research |
| Country Winds Manor, INC | Health Care and Social Assistance | $229,800 | $232,047 | 54 | N/A | Research |
| Cresco Building Service Inc. | Construction | $219,726 | $220,843 | 19 | $21.6M | Research |
| Bear Creek Archeolog, Inc. | Professional, Scientific, and Technical Services | $206,973 | $208,147 | 29 | $6.0M | Research |
| Cresco Building Service, INC | Construction | $195,700 | $196,874 | 18 | $20.5M | Research |
| Notre Dame Church Corporation | Other Services (except Public Administration) | $176,700 | $177,657 | 27 | N/A | Research |
| Notre Dame Church Corporation | Other Services (except Public Administration) | $169,892 | $170,515 | 32 | N/A | Research |
| Cresco Insurance Agency INC | Finance and Insurance | $160,900 | $161,782 | 13 | $6.7M | Research |
| Doug Reicks Trucking LLC | Transportation and Warehousing | $137,015 | $138,614 | 15 | <$5M | Research |
| Hawkeye Sanitation Inc. | Administrative and Support and Waste Management | $134,775 | $135,827 | 24 | <$5M | Research |
| Master Plastics Inc. | Manufacturing | $122,138 | $122,464 | 7 | $6.9M | Research |
| Howard County Child Care Association | Health Care and Social Assistance | $115,109 | $115,664 | 40 | N/A | Research |
| Fenco Products Inc. | Wholesale Trade | $110,900 | $111,513 | 12 | <$5M | Research |
| Masonry Technology, Inc. | Manufacturing | $107,595 | $108,406 | 8 | $7.9M | Research |
| Oak Creek Dental, Plc | Health Care and Social Assistance | $97,800 | $98,329 | 9 | <$5M | Research |
| Howard County Child Care Association | Health Care and Social Assistance | $96,744 | $97,224 | 40 | N/A | Research |