| Greater Regional Medical Center | Health Care and Social Assistance | $6,060,000 | $6,127,838 | 461 | $91.5M |  Research |
| R. E. Lewis Refrigeration, Inc. | Construction | $575,600 | $579,968 | 32 | $10.1M | Research |
| Precision Optical Group, INC | Manufacturing | $401,000 | $403,788 | 61 | $16.0M | Research |
| Precision Optical Group INC | Manufacturing | $401,000 | $403,139 | 40 | $10.5M | Research |
| Green Valley Chemical Corporation | Manufacturing | $393,750 | $396,495 | 35 | $34.7M | Research |
| Green Valley Chemical Corporation | Wholesale Trade | $393,750 | $395,784 | 36 | $9.3M | Research |
| Giza Landscaping & Lawn Care, LLC | Transportation and Warehousing | $365,500 | $370,140 | 49 | $13.1M | Research |
| Crossroads Behavioral Health Services | Health Care and Social Assistance | $348,700 | $349,959 | 36 | N/A | Research |
| Stalker Chevrolet | Retail Trade | $252,160 | $254,598 | 17 | <$5M | Research |
| Crossroads Behavioral Health Services | Health Care and Social Assistance | $210,700 | $352,594 | 27 | N/A | Research |
| Southwest Distributing Company | Wholesale Trade | $205,000 | $206,331 | 20 | $5.1M | Research |
| Innovative Industries INC | Manufacturing | $181,200 | $182,010 | 88 | $87.3M | Research |
| St. Malachy School | Educational Services | $168,400 | $169,560 | 20 | N/A | Research |
| Decorum Creston LLC | Accommodation and Food Services | $141,500 | $142,539 | 14 | <$5M | Research |
| Medicap Pharmacy | Retail Trade | $123,600 | $124,355 | 10 | <$5M | Research |
| Creston Veterinary Clinic PC | Professional, Scientific, and Technical Services | $118,200 | $119,142 | 11 | <$5M | Research |
| Brown Bear Corporation | Transportation and Warehousing | $115,900 | $116,570 | 12 | <$5M | Research |
| Jeromy Burgmaier | Agriculture, Forestry, Fishing and Hunting | $108,670 | $109,018 | 9 | <$5M | Research |
| Michael D Buck Dds, PC | Health Care and Social Assistance | $107,600 | $108,536 | 11 | <$5M | Research |
| Green Valley Pest Control & Lawn Care, INC | Administrative and Support and Waste Management | $105,400 | $105,986 | 16 | <$5M | Research |
| Jim's Truck Repair INC | Other Services (except Public Administration) | $102,300 | $103,030 | 9 | <$5M | Research |
| Max Smith | Construction | $100,100 | $100,575 | 5 | <$5M | Research |
| Max Smith Construction | Construction | $100,100 | $100,598 | 14 | $16.0M | Research |
| Grapevine Staffing LLC | Administrative and Support and Waste Management | $98,000 | $98,512 | 9 | <$5M | Research |
| Creston Vision Clinic PC | Health Care and Social Assistance | $96,600 | $97,048 | 9 | <$5M | Research |