| Palo Alto County Hospital | Health Care and Social Assistance | $2,552,643 | $2,581,876 | 328 | N/A |  Research |
| Wild Rose Emmetsburg LLC | Accommodation and Food Services | $1,805,603 | $1,814,903 | 95 | $29.7M | Research |
| Wild Rose Emmetsburg, LLC | Accommodation and Food Services | $1,270,100 | $1,282,766 | 144 | $45.0M | Research |
| Lakeside Lutheran Home | Health Care and Social Assistance | $466,402 | $468,971 | 81 | N/A | Research |
| Horizons Unlimited of Palo Alto County, Inc. | Health Care and Social Assistance | $365,591 | $367,394 | 50 | N/A | Research |
| Kathleen's Residential Care, Inc. | Health Care and Social Assistance | $226,188 | $227,758 | 34 | $5.8M | Research |
| Hughes Pharmacy Services, Inc. | Retail Trade | $175,797 | $176,867 | 46 | $8.0M | Research |
| Asi Contracting, INC | Other Services (except Public Administration) | $173,800 | $175,441 | 36 | $7.7M | Research |
| Holy Family Parish | Other Services (except Public Administration) | $136,216 | $137,089 | 32 | N/A | Research |
| Holy Family Parish | Educational Services | $126,276 | $126,781 | 43 | N/A | Research |
| Jmd Ventures INC | Accommodation and Food Services | $126,200 | $127,041 | 43 | $7.6M | Research |
| C & S Brownlee Farms Partnership | Agriculture, Forestry, Fishing and Hunting | $103,772 | $104,248 | 6 | <$5M | Research |
| C & S Brownlee Farms Partnership | Agriculture, Forestry, Fishing and Hunting | $103,700 | $104,334 | 7 | <$5M | Research |
| Woodford Equipment, Inc. | Wholesale Trade | $103,629 | $104,387 | 10 | <$5M | Research |
| Smarts Broadcast Systems | Professional, Scientific, and Technical Services | $101,651 | $102,158 | 14 | <$5M | Research |
| Woodford Equipment Inc. | Wholesale Trade | $100,857 | $101,341 | 11 | <$5M | Research |
| D.j. Foods Inc. | Accommodation and Food Services | $90,776 | $91,323 | 32 | $5.7M | Research |
| Jensvold Motor Co | Retail Trade | $89,647 | $90,224 | 10 | <$5M | Research |
| Emmetsburg Eye Clinic | Health Care and Social Assistance | $78,685 | $79,168 | 11 | <$5M | Research |
| Family Table of Emmetsburg Ltd | Accommodation and Food Services | $77,136 | $77,530 | 18 | <$5M | Research |
| Agri Services of Northern Iowa | Retail Trade | $77,100 | $77,655 | 7 | <$5M | Research |
| Emmetsburg Eye Clinic | Health Care and Social Assistance | $75,501 | $75,862 | 8 | <$5M | Research |
| Jimglo Inc. | Wholesale Trade | $74,830 | $75,291 | 8 | <$5M | Research |
| Asi Commercial Construction Services INC | Construction | $72,076 | $72,432 | 5 | $5.7M | Research |
| Firkins Truck Line, Inc. | Transportation and Warehousing | $66,200 | $66,543 | 7 | <$5M | Research |