| Guthrie County Hospital | Health Care and Social Assistance | $1,601,942 | $1,611,643 | 139 | N/A |  Research |
| The Capstone Group, Inc. | Health Care and Social Assistance | $479,600 | $797,834 | 88 | N/A | Research |
| Reinhart Bros Inc. | Retail Trade | $383,683 | $387,381 | 100 | $25.0M | Research |
| Country View Estates, Inc. | Health Care and Social Assistance | $267,707 | $269,592 | 40 | N/A | Research |
| Guthrie County Rural Electric Cooperative Association | Utilities | $259,397 | $261,263 | 17 | N/A | Research |
| Dica Marketing Company, Inc. | Manufacturing | $235,000 | $297,161 | 16 | $15.9M | Research |
| Wild, Baxter & Sand, P.c. | Professional, Scientific, and Technical Services | $102,400 | $103,127 | 8 | N/A | Research |
| Asset Inspections INC | Administrative and Support and Waste Management | $92,400 | $92,895 | 7 | <$5M | Research |
| Guthrie Family Medicine Center Plc | Health Care and Social Assistance | $91,553 | $92,235 | 8 | <$5M | Research |
| Dowd Drug, Inc. | Retail Trade | $86,763 | $87,498 | 14 | <$5M | Research |
| Guthrie Family Medicine Center | Health Care and Social Assistance | $79,185 | $115,271 | 8 | <$5M | Research |
| Guthrie Center Assembly, LLC | Manufacturing | $77,622 | $78,137 | 14 | <$5M | Research |
| Gc Subs, INC | Accommodation and Food Services | $72,000 | $72,602 | 38 | $6.7M | Research |
| Van Meter Feedyard, LLC | Agriculture, Forestry, Fishing and Hunting | $64,200 | $64,776 | 7 | <$5M | Research |
| Van Meter Feedyard LLC | Agriculture, Forestry, Fishing and Hunting | $64,200 | $64,487 | 7 | <$5M | Research |
| Guthrie County Veterinary Services INC | Professional, Scientific, and Technical Services | $61,200 | $61,622 | 6 | <$5M | Research |
| Guthrie County Abstract Company | Real Estate and Rental and Leasing | $56,300 | $56,758 | 4 | <$5M | Research |
| Jorgensen Brothers Concrete Construction, Inc. | Construction | $54,161 | $54,457 | 6 | <$5M | Research |
| Doug's Plumbing & Heating, INC | Construction | $49,319 | $49,589 | 7 | <$5M | Research |
| Guthrie Stock Pavilion Co Corp. | Administrative and Support and Waste Management | $45,394 | $45,850 | 12 | <$5M | Research |
| Lisa Calvert | Professional, Scientific, and Technical Services | $44,927 | $45,198 | 4 | <$5M | Research |
| Lisa A. Calvert CPA | Professional, Scientific, and Technical Services | $44,927 | $45,187 | 6 | <$5M | Research |
| Robert Carr Insurance Agency Inc. | Finance and Insurance | $42,100 | $42,364 | 5 | <$5M | Research |
| Double K Built LLC | Construction | $41,667 | $41,837 | 2 | <$5M | Research |
| Double K Built, LLC | Construction | $41,667 | $41,974 | 2 | <$5M | Research |