| Mitchell County Memorial Hospital | Health Care and Social Assistance | $2,480,100 | $2,508,552 | 246 | N/A |  Research |
| Great Socks Holding Co. LLC | Manufacturing | $1,735,409 | $1,746,249 | 124 | $43.8M | Research |
| Great Socks Holding Co., LLC | Manufacturing | $1,735,400 | $1,750,329 | 101 | $35.6M | Research |
| A to Z Drying, Inc. | Manufacturing | $1,330,750 | $1,340,958 | 116 | $115.1M | Research |
| Osage Cooperative Elevator | Wholesale Trade | $600,980 | $605,014 | 40 | $10.3M | Research |
| Faith Lutheran Home Corporation | Health Care and Social Assistance | $570,000 | $574,623 | 65 | N/A | Research |
| The Art of Education University, LLC | Educational Services | $457,880 | $460,411 | 73 | $8.8M | Research |
| Popp Excavating Inc. | Construction | $255,619 | $256,950 | 15 | $5.6M | Research |
| Popp Excavating, Inc. | Construction | $242,127 | $243,852 | 15 | $5.6M | Research |
| Mark's Tractor & Implement, INC | Wholesale Trade | $162,890 | $164,080 | 17 | $5.2M | Research |
| Murphy, Coe & Smith, P.l.l.c. | Professional, Scientific, and Technical Services | $151,607 | $152,691 | 17 | $5.4M | Research |
| Adams Plumbing & Heating INC | Construction | $144,409 | $145,283 | 13 | <$5M | Research |
| Adams Plumbing & Heating INC | Construction | $144,409 | $144,967 | 13 | <$5M | Research |
| Osage Food Bank INC | Retail Trade | $123,000 | $123,772 | 32 | $8.0M | Research |
| D. Randall Construction, LLC | Construction | $109,500 | $110,376 | 8 | <$5M | Research |
| Osage Grillhouse Company LLC | Accommodation and Food Services | $106,330 | $106,980 | 13 | <$5M | Research |
| Osage Veterinary Clinic, P.c. | Professional, Scientific, and Technical Services | $105,700 | $106,904 | 7 | <$5M | Research |
| Nack & Associates | Construction | $101,530 | $102,241 | 6 | $6.8M | Research |
| Nack & Associates, Inc. | Agriculture, Forestry, Fishing and Hunting | $101,500 | $102,366 | 6 | <$5M | Research |
| Synergy Partners, Inc. | Agriculture, Forestry, Fishing and Hunting | $94,100 | $94,983 | 8 | <$5M | Research |
| Pollard Pest Control Co | Administrative and Support and Waste Management | $88,000 | $88,645 | 11 | <$5M | Research |
| Mayer's Excavating Company | Construction | $78,800 | $79,384 | 10 | <$5M | Research |
| Osage Express INC | Transportation and Warehousing | $75,500 | $76,152 | 9 | <$5M | Research |
| Ken Corp. | Transportation and Warehousing | $75,255 | $75,803 | 14 | <$5M | Research |
| Patterson Seed Ltd. | Wholesale Trade | $73,429 | $74,155 | 5 | <$5M | Research |