| Shenandoah Medical Center | Health Care and Social Assistance | $3,558,900 | $3,592,116 | 331 | N/A |  Research |
| Nishna Productions INC | Health Care and Social Assistance | $1,476,300 | $1,484,748 | 250 | N/A | Research |
| Browns Shoe Fit Co General Office INC | Administrative and Support and Waste Management | $296,200 | $298,422 | 30 | $5.7M | Research |
| Shenandoah Family Dentistry | Health Care and Social Assistance | $175,500 | $176,498 | 13 | <$5M | Research |
| Shenandoah Family Dentistry | Health Care and Social Assistance | $175,500 | $176,173 | 13 | <$5M | Research |
| Kmaland Broadcasting | Information | $175,200 | $176,188 | 13 | <$5M | Research |
| United Group Insurance, Inc. | Finance and Insurance | $173,700 | $174,718 | 17 | $8.7M | Research |
| Eyecare Associates of Southwest Iowa, INC | Health Care and Social Assistance | $164,200 | $165,231 | 14 | <$5M | Research |
| Triple K Manufacturing, Inc. | Manufacturing | $153,300 | $156,072 | 14 | <$5M | Research |
| Eyecare Associates of Southwest Iowa Inc. | Health Care and Social Assistance | $146,500 | $147,082 | 16 | <$5M | Research |
| Southwest Iowa Dental Associates | Health Care and Social Assistance | $127,412 | $127,848 | 14 | <$5M | Research |
| Southwest Iowa Dental Associates, Inc. | Health Care and Social Assistance | $115,206 | $116,197 | 11 | <$5M | Research |
| Lashier, Bonefas, Baldwin & Co., P.c. | Professional, Scientific, and Technical Services | $100,000 | $100,756 | 9 | <$5M | Research |
| Our House Child Development Center | Other Services (except Public Administration) | $85,000 | $85,431 | 32 | $6.1M | Research |
| Our House Child Care Development Center | Health Care and Social Assistance | $85,000 | $85,394 | 20 | <$5M | Research |
| William Hillman | Accommodation and Food Services | $82,260 | $82,813 | 69 | $12.3M | Research |
| Elm Street Corporation | Finance and Insurance | $82,000 | $82,364 | 7 | <$5M | Research |
| Elm Street Corporation | Finance and Insurance | $79,300 | $79,994 | 6 | <$5M | Research |
| El Porton Huerta Inc. | Accommodation and Food Services | $74,300 | $74,731 | 11 | <$5M | Research |
| Depot Deli and Fire House Brew | Accommodation and Food Services | $73,195 | $73,693 | 42 | $7.5M | Research |
| Tall Corn Ag Inc. | Wholesale Trade | $70,907 | $71,155 | 8 | <$5M | Research |
| Tall Corn Ag, Inc. | Agriculture, Forestry, Fishing and Hunting | $70,900 | $71,339 | 8 | <$5M | Research |
| Shenandoah Animal Hospital, Inc. | Professional, Scientific, and Technical Services | $63,000 | $63,329 | 7 | <$5M | Research |
| Premier Healthcare of Shenandoah PC | Health Care and Social Assistance | $57,825 | $58,198 | 7 | <$5M | Research |
| R & R Concrete Contractors Inc. | Construction | $57,774 | $58,098 | 7 | <$5M | Research |