| Thompson Electric Company | Construction | $5,954,493 | $6,031,074 | 315 | $103.6M |  Research |
| State Steel Supply Co. | Manufacturing | $4,695,700 | $4,750,744 | 336 | $88.0M | Research |
| Sioux City Truck Sales INC | Wholesale Trade | $4,213,000 | $4,266,326 | 316 | $96.8M | Research |
| Morningside College | Educational Services | $4,042,655 | $4,078,141 | 493 | N/A | Research |
| Sce Partners LLC | Accommodation and Food Services | $3,733,855 | $3,050,584 | 484 | $151.3M | Research |
| Aventure Capital, LLC | Administrative and Support and Waste Management | $3,642,716 | $3,685,113 | 500 | $78.7M | Research |
| Tip Top Tux LLC | Real Estate and Rental and Leasing | $3,125,319 | $3,166,590 | 500 | $225.9M | Research |
| Family Health Care of Siouxland P.l.c. | Health Care and Social Assistance | $2,975,700 | $3,477,429 | 290 | $91.0M | Research |
| Goodwill of the Great Plains | Retail Trade | $2,755,393 | $2,769,017 | 277 | $52.5M | Research |
| Siouxland Community Health Center | Health Care and Social Assistance | $2,292,430 | $2,318,920 | 159 | N/A | Research |
| Sioux City Foundry Company | Manufacturing | $2,278,800 | $2,304,522 | 219 | $57.3M | Research |
| Premier Services, Inc. | Administrative and Support and Waste Management | $2,265,885 | $2,292,320 | 336 | $52.9M | Research |
| Palmer and Company | Manufacturing | $2,037,900 | $2,061,350 | 211 | $74.5M | Research |
| Tip Top Tux LLC | Real Estate and Rental and Leasing | $2,000,000 | $2,024,000 | 287 | $129.7M | Research |
| Sioux City Foundry Company | Manufacturing | $2,000,000 | $2,010,356 | 165 | $43.2M | Research |
| Premier Services Inc. | Administrative and Support and Waste Management | $2,000,000 | $2,008,556 | 282 | $44.4M | Research |
| American Pop Corn Company | Manufacturing | $1,963,700 | $1,981,669 | 170 | $60.0M | Research |
| Short Staffed, Inc. | Administrative and Support and Waste Management | $1,923,600 | $1,942,996 | 456 | $71.8M | Research |
| Briar Cliff University | Educational Services | $1,853,600 | $2,438,320 | 183 | N/A | Research |
| C. W. Suter & Son, Inc. and El | Construction | $1,826,000 | $1,841,775 | 132 | $41.8M | Research |
| Bishop Heelan Catholic Schools | Educational Services | $1,650,000 | $1,661,963 | 184 | N/A | Research |
| Industrial Design Fabrication & Installation, Inc. | Manufacturing | $1,463,900 | $1,472,236 | 90 | $25.1M | Research |
| Dennis Supply Company | Wholesale Trade | $1,259,625 | $1,271,591 | 87 | $26.7M | Research |
| Siouxland Regional Cancer Center | Health Care and Social Assistance | $1,239,600 | $0 | 93 | N/A | Research |
| Sunrise Retirement Community Foundation | Health Care and Social Assistance | $1,206,664 | $1,212,648 | 144 | N/A | Research |