| Employee Resource Group, LLC | Accommodation and Food Services | $7,834,500 | $7,926,338 | 50 | $8.9M |  Research |
| Primary Care Centers of Eastern Kentucky LLC | Health Care and Social Assistance | $3,021,900 | $3,061,971 | 250 | $78.5M | Research |
| Leslie, Knott, Letcher, Perry Community Action Council | Public Administration | $1,854,605 | $1,868,324 | 334 | N/A | Research |
| Quantum Healthcare Associates Psc | Health Care and Social Assistance | $1,100,000 | $1,106,268 | 72 | $12.8M | Research |
| Aaa Mine Service INC | Other Services (except Public Administration) | $704,300 | $711,825 | 44 | $9.5M | Research |
| Eastern Kentucky C.e.p., Inc. | Public Administration | $684,600 | $688,842 | 41 | N/A | Research |
| Fast Staff, LLC | Administrative and Support and Waste Management | $596,700 | $602,501 | 200 | $31.5M | Research |
| Aaa Mine Service INC | Other Services (except Public Administration) | $593,300 | $597,965 | 42 | $9.0M | Research |
| Tim Short Chrysler, LLC | Retail Trade | $585,600 | $592,530 | 82 | $20.7M | Research |
| Perry Distributors Inc. | Wholesale Trade | $561,200 | $567,535 | 42 | $10.8M | Research |
| Alternative Outlook LLC | Health Care and Social Assistance | $445,200 | $448,469 | 25 | <$5M | Research |
| Tm Short Hazard LLC | Retail Trade | $411,400 | $416,268 | 47 | $11.8M | Research |
| Tim Short Ford Lincoln | Retail Trade | $380,400 | $384,901 | 58 | $14.6M | Research |
| Mine Service Company, Inc. | Manufacturing | $367,230 | $369,383 | 25 | $6.5M | Research |
| Soaring Potentials Lllp | Health Care and Social Assistance | $357,300 | $362,097 | 65 | $11.1M | Research |
| Perry County Ambulance Authority | Health Care and Social Assistance | $318,558 | $319,407 | 41 | $9.5M | Research |
| Perry County Ambulance Authority Inc. | Health Care and Social Assistance | $318,558 | $319,796 | 41 | $9.5M | Research |
| Fugate Family Chiropractic, P.s.c. | Health Care and Social Assistance | $317,384 | $320,732 | 23 | $5.4M | Research |
| Fugate Family Chiropractic, P.s.c. | Health Care and Social Assistance | $317,382 | $319,208 | 23 | $5.4M | Research |
| Kentucky Pain Management Services LLC | Health Care and Social Assistance | $310,400 | $313,955 | 23 | $7.2M | Research |
| Housing Development Alliance, INC | Construction | $285,500 | $288,457 | 29 | N/A | Research |
| Mountain After-Hours Clinic, Psc | Health Care and Social Assistance | $281,800 | $285,290 | 34 | $10.7M | Research |
| Housing Development Alliance, INC | Construction | $263,700 | $266,539 | 28 | N/A | Research |
| Clutts Auto Sales, Inc. | Wholesale Trade | $244,195 | $245,934 | 26 | $8.0M | Research |
| Clutts Auto Sales Inc. | Retail Trade | $243,908 | $246,012 | 23 | $5.8M | Research |