| Mountain Comprehensive Health Corporation | Health Care and Social Assistance | $2,729,500 | $2,760,534 | 392 | $69.8M |  Research |
| Hometown Convenience LLC | Retail Trade | $2,395,900 | $2,427,313 | 500 | $167.3M | Research |
| Appalachian Rehabilitation Team, Inc. | Health Care and Social Assistance | $361,735 | $339,680 | 40 | $10.8M | Research |
| Appalachian Rehabilitation Team Inc. | Health Care and Social Assistance | $336,993 | $339,578 | 31 | $8.4M | Research |
| London Auto Truck Center INC | Retail Trade | $274,500 | $277,908 | 65 | $21.8M | Research |
| Appalshop, Inc. | Public Administration | $262,300 | $264,384 | 25 | N/A | Research |
| Comfort Hills, LLC | Health Care and Social Assistance | $162,241 | $163,796 | 37 | $6.3M | Research |
| Appalachian Citizens Law Center Inc. | Professional, Scientific, and Technical Services | $160,400 | $161,894 | 11 | N/A | Research |
| Medicorp INC | Retail Trade | $159,400 | $161,051 | 25 | <$5M | Research |
| Childers Oil Co | Accommodation and Food Services | $148,500 | $150,459 | 48 | $8.5M | Research |
| Appalachian Citizens Law Center, Inc. | Professional, Scientific, and Technical Services | $144,800 | $146,093 | 10 | N/A | Research |
| Housing Oriented Ministries Established for Service Inc. | Construction | $136,200 | $136,767 | 17 | $5.2M | Research |
| Childers Contracting, Inc. | Construction | $132,000 | $133,492 | 18 | $20.5M | Research |
| Drill Steel Services | Mining, Quarrying, and Oil and Gas Extraction | $125,600 | $126,737 | 13 | <$5M | Research |
| Center for Rural Strategies | Public Administration | $109,700 | $110,617 | 8 | N/A | Research |
| D.k. Williams P.s.c. | Health Care and Social Assistance | $106,800 | $107,660 | 11 | <$5M | Research |
| Jacobs Ward Psc | Professional, Scientific, and Technical Services | $100,000 | $100,703 | 7 | <$5M | Research |
| Mountain Heart Center, Psc | Health Care and Social Assistance | $100,000 | $101,271 | 11 | <$5M | Research |
| Jacobs Ward Psc | Professional, Scientific, and Technical Services | $100,000 | $100,863 | 6 | <$5M | Research |
| Frazier's Farmer Supply Company, INC | Retail Trade | $98,200 | $99,064 | 22 | <$5M | Research |
| Kwik Shop Concepts, INC | Retail Trade | $84,700 | $85,839 | 28 | $7.0M | Research |
| Childers Transport, Inc. | Wholesale Trade | $79,700 | $80,643 | 13 | <$5M | Research |
| Letcher Funeral Home Incorporated | Other Services (except Public Administration) | $75,000 | $75,645 | 9 | <$5M | Research |
| Dz Managment, INC | Accommodation and Food Services | $71,012 | $71,697 | 24 | <$5M | Research |
| J & J Bates Trucking INC | Transportation and Warehousing | $57,900 | $58,430 | 8 | <$5M | Research |