| Acadia Wholesale and Tobacco Company, INC | Wholesale Trade | $1,594,700 | $1,603,692 | 171 | $44.0M |  Research |
| Acadia St. Landry Hospital | Health Care and Social Assistance | $1,164,200 | $1,175,034 | 111 | $22.0M | Research |
| Support Healthcare Systems, Inc. | Health Care and Social Assistance | $730,500 | $739,986 | 416 | $71.3M | Research |
| Acadia - St. Landry Guest Home | Health Care and Social Assistance | $600,600 | $696,888 | 95 | $16.2M | Research |
| C'est Bon Seafood L.l.c. | Agriculture, Forestry, Fishing and Hunting | $534,352 | $538,478 | 51 | $8.3M | Research |
| Rod's Thrif-T Mart INC | Retail Trade | $288,500 | $290,167 | 70 | $17.5M | Research |
| Kellys Grocery & Market, Inc. | Retail Trade | $258,353 | $260,742 | 55 | $13.7M | Research |
| Neighbors Pharmacy, LLC | Retail Trade | $246,970 | $250,119 | 19 | <$5M | Research |
| Levin Savoy | Agriculture, Forestry, Fishing and Hunting | $213,567 | $215,744 | 14 | <$5M | Research |
| Church Point Drug Inc. | Retail Trade | $196,400 | $198,907 | 36 | $6.3M | Research |
| Venable Construction Company INC | Construction | $165,238 | $166,155 | 15 | <$5M | Research |
| Levin Savoy | Agriculture, Forestry, Fishing and Hunting | $164,976 | $166,401 | 26 | <$5M | Research |
| Our Mother of Peace Elementary School, INC | Other Services (except Public Administration) | $149,800 | $151,489 | 32 | N/A | Research |
| Venable Construction Company, Inc. | Construction | $140,835 | $141,645 | 18 | <$5M | Research |
| Power Cleaning Solutions, L.l.c. | Administrative and Support and Waste Management | $126,275 | $119,854 | 4 | <$5M | Research |
| Richmond's INC | Accommodation and Food Services | $121,070 | $122,102 | 37 | $6.6M | Research |
| Felton Family Care INC | Health Care and Social Assistance | $100,400 | $101,889 | 13 | <$5M | Research |
| Acadian Dusters LLC | Agriculture, Forestry, Fishing and Hunting | $99,735 | $100,987 | 8 | <$5M | Research |
| Church Point Community Pharmacy, Llc. | Retail Trade | $99,500 | $100,216 | 14 | <$5M | Research |
| Church Point Community Pharmacy, Llc. | Retail Trade | $99,050 | $100,324 | 11 | <$5M | Research |
| Bec Vision, LLC | Health Care and Social Assistance | $94,802 | $95,400 | 16 | <$5M | Research |
| Gianfala & Son INC | Mining, Quarrying, and Oil and Gas Extraction | $86,684 | $87,043 | 10 | <$5M | Research |
| Gianfala and Son, INC | Mining, Quarrying, and Oil and Gas Extraction | $86,600 | $87,329 | 13 | <$5M | Research |
| Vautrot's Mini Mart, LLC | Retail Trade | $85,000 | $85,470 | 25 | $6.2M | Research |
| Acadian Dusters | Agriculture, Forestry, Fishing and Hunting | $84,700 | $85,429 | 8 | <$5M | Research |