| Center for Orthopedics and Spine | Health Care and Social Assistance | $758,800 | $765,328 | 88 | $27.6M |  Research |
| Sweet Lake Land & Oil Co. LLC | Real Estate and Rental and Leasing | $741,600 | $750,479 | 44 | $5.1M | Research |
| Sweet Lake Land and Oil Co., LLC | Mining, Quarrying, and Oil and Gas Extraction | $741,500 | $746,526 | 44 | <$5M | Research |
| Lake Charles Catholic High School | Educational Services | $712,260 | $712,347 | 72 | N/A | Research |
| Stockwell Sievert Viccellio Clements and Shaddock LLP | Professional, Scientific, and Technical Services | $711,458 | $717,792 | 51 | $12.4M | Research |
| Precision Pump & Valve, L.l.c. | Manufacturing | $702,962 | $713,429 | 52 | $13.6M | Research |
| Dubois Sheet Metal | Manufacturing | $697,402 | $701,606 | 49 | $12.0M | Research |
| Dubois Sheet Metal Works LLC | Construction | $680,167 | $689,746 | 49 | $15.5M | Research |
| Lake Area Electrical & Technical Services, L.l.c. | Construction | $658,004 | $656,861 | 42 | $13.8M | Research |
| Prokar INC | Transportation and Warehousing | $647,163 | $650,344 | 49 | <$5M | Research |
| Charleston Waco Operations, LLC | Health Care and Social Assistance | $644,600 | $653,463 | 89 | $15.1M | Research |
| Alfred Palma, LLC | Construction | $637,435 | $645,765 | 42 | $47.9M | Research |
| Cooper Manufacturing & Supply Inc. | Manufacturing | $630,000 | $636,143 | 14 | $13.9M | Research |
| Alfred Palma LLC | Construction | $627,435 | $634,895 | 42 | $47.9M | Research |
| Custom Metal Fabricators | Construction | $622,793 | $0 | 40 | $15.0M | Research |
| Society of the Roman Catholic Church Diocese of Lake Charles | Other Services (except Public Administration) | $615,385 | $757,244 | 64 | N/A | Research |
| Darbonne Services, Inc. | Professional, Scientific, and Technical Services | $611,746 | $619,739 | 70 | $7.2M | Research |
| Darbonne Services INC | Professional, Scientific, and Technical Services | $611,745 | $616,258 | 64 | $9.0M | Research |
| Cox, Cox, Filo, Camel and Wilson, LLC | Professional, Scientific, and Technical Services | $611,200 | $616,208 | 49 | $11.9M | Research |
| Sabine Pool Supplies, LLC | Wholesale Trade | $608,700 | $616,072 | 48 | $14.7M | Research |
| High Hope Rehabilitation and Nursing Center, L.l.c. | Health Care and Social Assistance | $607,700 | $616,056 | 88 | $15.0M | Research |
| Murphy Cormier General Contractor, Inc. | Construction | $595,700 | $601,690 | 59 | $18.3M | Research |
| Pitt Grill INC | Accommodation and Food Services | $593,463 | $585,475 | 120 | $21.3M | Research |
| Navarre Nissan, LLC | Retail Trade | $592,400 | $598,340 | 45 | $11.3M | Research |
| Beverage Sales INC | Wholesale Trade | $591,230 | $598,211 | 75 | $19.3M | Research |