| Clhg-Avoyelles LLC | Health Care and Social Assistance | $1,580,145 | $1,608,891 | 282 | $88.5M |  Research |
| Tunica Biloxi Tribe of Louisiana | Public Administration | $787,723 | $794,521 | 90 | N/A | Research |
| Lakeview Manor INC | Health Care and Social Assistance | $642,500 | $650,460 | 121 | $20.6M | Research |
| Hessmer Nursing Home INC | Health Care and Social Assistance | $554,900 | $561,775 | 107 | $18.2M | Research |
| Colonial Nursing Home, INC | Health Care and Social Assistance | $450,200 | $455,777 | 72 | $12.2M | Research |
| Mobiloans LLC | Finance and Insurance | $303,302 | $0 | 37 | N/A | Research |
| Brian Caubarreaux & Associates Aplc | Professional, Scientific, and Technical Services | $266,855 | $268,756 | 19 | <$5M | Research |
| Brian Caubarreaux & Associates Aplc | Professional, Scientific, and Technical Services | $219,082 | $220,997 | 23 | $5.6M | Research |
| Darrel D Ryland, LLC | Professional, Scientific, and Technical Services | $218,700 | $220,006 | 10 | <$5M | Research |
| Crawfish Processing, LLC | Manufacturing | $194,338 | $196,313 | 60 | $21.2M | Research |
| Hospice Care of Avoyelles LLC | Health Care and Social Assistance | $175,707 | $178,533 | 35 | $6.0M | Research |
| Darrel D Ryland LLC | Professional, Scientific, and Technical Services | $147,350 | $148,000 | 10 | <$5M | Research |
| Roy Scott & James | Professional, Scientific, and Technical Services | $132,980 | $133,963 | 6 | <$5M | Research |
| Roy, Scott & James, LLC | Professional, Scientific, and Technical Services | $132,900 | $133,720 | 8 | <$5M | Research |
| Fresh Catch Bistreaux LLC | Accommodation and Food Services | $129,684 | $130,402 | 24 | <$5M | Research |
| Smart Repair Group of Louisiana, LLC | Other Services (except Public Administration) | $126,700 | $127,519 | 35 | $6.9M | Research |
| Hospice Care of Avoyelles Parish, LLC | Health Care and Social Assistance | $126,643 | $127,896 | 24 | <$5M | Research |
| River Runs Dirt Service LLC | Construction | $125,160 | $125,862 | 15 | $5.6M | Research |
| S. Lewis Contractor LLC | Construction | $121,000 | $35,160 | 25 | <$5M | Research |
| S Lewis Contractors LLC | Construction | $113,803 | $114,155 | 20 | <$5M | Research |
| Avoyelles Timber Inc. | Agriculture, Forestry, Fishing and Hunting | $104,573 | $105,123 | 11 | <$5M | Research |
| Donna Breen | Health Care and Social Assistance | $94,412 | $94,950 | 13 | <$5M | Research |
| Therapy Center of Avoyelles LLC | Health Care and Social Assistance | $90,000 | $90,615 | 7 | <$5M | Research |
| Therapy Center of Avoyelles, LLC | Health Care and Social Assistance | $89,900 | $90,477 | 7 | <$5M | Research |
| Donna L Breen MD | Health Care and Social Assistance | $88,184 | $88,776 | 12 | <$5M | Research |