| Pointe Coupee Parish Health Services District Number One | Health Care and Social Assistance | $1,999,946 | $2,026,137 | 140 | N/A |  Research |
| Louisiana Workforce LLC | Health Care and Social Assistance | $1,119,898 | $1,124,868 | 115 | $18.6M | Research |
| Louisiana Workforce, LLC | Health Care and Social Assistance | $1,036,586 | $1,045,560 | 202 | $32.7M | Research |
| The Pangburn Group, Inc. | Professional, Scientific, and Technical Services | $929,365 | $935,094 | 56 | $5.8M | Research |
| Pointe Coupee Healthcare, LLC | Real Estate and Rental and Leasing | $725,400 | $730,740 | 120 | $18.0M | Research |
| Pointe Coupee Electric Membership Corporation | Utilities | $713,700 | $718,399 | 42 | N/A | Research |
| Chustz Surveying LLC | Professional, Scientific, and Technical Services | $533,923 | $538,150 | 59 | $7.3M | Research |
| Catholic School Board of Pointe Coupee | Educational Services | $532,900 | $540,054 | 71 | N/A | Research |
| Chustz Surveying LLC | Professional, Scientific, and Technical Services | $483,023 | $485,988 | 36 | <$5M | Research |
| Pointe Coupee Parish Hospital Service District Number One | Health Care and Social Assistance | $312,000 | $315,701 | 40 | N/A | Research |
| Bellelo's Furniture and Appliances, LLC | Retail Trade | $268,183 | $269,947 | 31 | $5.6M | Research |
| Lacours Health Care Center LLC | Health Care and Social Assistance | $264,364 | $267,334 | 65 | $11.1M | Research |
| Pointe Coupee Private School System, INC | Educational Services | $262,077 | $263,654 | 35 | <$5M | Research |
| Morel G. Lemoine Distributor, Inc. | Retail Trade | $215,849 | $217,404 | 12 | <$5M | Research |
| Morel G Lemoine Distributors INC | Wholesale Trade | $215,459 | $216,474 | 12 | <$5M | Research |
| Fontaine Lumber Company, INC | Retail Trade | $182,398 | $183,657 | 24 | <$5M | Research |
| H J Bergeron Pecan Shelling Plant LLC | Agriculture, Forestry, Fishing and Hunting | $174,934 | $175,911 | 29 | <$5M | Research |
| H.j. Bergeron Pecan Shelling Plant, LLC | Agriculture, Forestry, Fishing and Hunting | $174,934 | $176,271 | 29 | <$5M | Research |
| Ewings of New Roads INC | Accommodation and Food Services | $169,600 | $171,375 | 49 | $8.7M | Research |
| Pointe Coupee Outreach Center, INC | Educational Services | $160,400 | $161,674 | 70 | $9.1M | Research |
| New Roads Motor Co. LLC | Retail Trade | $153,710 | $154,481 | 16 | <$5M | Research |
| New Roads Motor Co. LLC | Retail Trade | $153,700 | $154,530 | 16 | <$5M | Research |
| Carroll Cuisine Concepts LLC | Accommodation and Food Services | $153,066 | $155,243 | 27 | <$5M | Research |
| America's Best Signs, LLC | Wholesale Trade | $150,500 | $152,492 | 22 | $6.7M | Research |
| Ewing's of False River LLC | Retail Trade | $137,453 | $137,999 | 14 | <$5M | Research |