| Governor's Holding INC | Accommodation and Food Services | $1,656,124 | $1,666,382 | 210 | $37.3M |  Research |
| Labree's | Manufacturing | $1,281,300 | $1,289,735 | 196 | $69.2M | Research |
| John T Cyr & Sons INC | Transportation and Warehousing | $1,225,695 | $1,235,262 | 220 | $84.6M | Research |
| John T Cyr & Sons, INC | Transportation and Warehousing | $1,101,864 | $1,107,955 | 220 | $84.6M | Research |
| James W. Sewall Company | Professional, Scientific, and Technical Services | $682,800 | $689,476 | 47 | $5.8M | Research |
| Governor's Holding, INC | Manufacturing | $650,000 | $653,665 | 239 | $84.4M | Research |
| Production Services of Maine LLC | Arts, Entertainment, and Recreation | $455,900 | $109,536 | 58 | $15.2M | Research |
| The Young Men's Christian Association of Old Town and Orono | Other Services (except Public Administration) | $374,100 | $376,386 | 140 | N/A | Research |
| Owen J Folsom INC | Retail Trade | $333,200 | $335,320 | 24 | <$5M | Research |
| Old Town-Orono Ymca | Other Services (except Public Administration) | $305,671 | $306,860 | 105 | N/A | Research |
| Waterfront Concerts LLC | Arts, Entertainment, and Recreation | $286,400 | $289,288 | 24 | $6.3M | Research |
| Facility and Construction Services, LLC | Construction | $267,087 | $213,959 | 16 | <$5M | Research |
| Carmichael Transport, Inc. | Transportation and Warehousing | $265,400 | $267,590 | 38 | $7.7M | Research |
| Waterfront Concerts LLC | Arts, Entertainment, and Recreation | $235,500 | $237,554 | 16 | <$5M | Research |
| Duprey Enterprises, INC | Health Care and Social Assistance | $218,200 | $220,298 | 45 | $7.3M | Research |
| Madden Timberlands INC | Agriculture, Forestry, Fishing and Hunting | $214,306 | $216,830 | 19 | <$5M | Research |
| Madden Timberlands INC | Agriculture, Forestry, Fishing and Hunting | $199,300 | $200,828 | 23 | <$5M | Research |
| Facility and Construction Services LLC | Construction | $198,902 | $201,615 | 18 | $5.6M | Research |
| Sullivan's Automotive Service INC | Other Services (except Public Administration) | $197,803 | $198,951 | 22 | <$5M | Research |
| Keith Trembley Builder INC | Construction | $185,253 | $186,324 | 22 | $6.7M | Research |
| Mckay Shared Living Services | Health Care and Social Assistance | $184,134 | $185,133 | 31 | $5.3M | Research |
| Dirigo Slipform | Construction | $179,141 | $180,196 | 18 | $5.6M | Research |
| Street's Landscape & Lawn Care INC | Administrative and Support and Waste Management | $169,975 | $170,858 | 20 | <$5M | Research |
| Sullivan's Automotive Service INC | Other Services (except Public Administration) | $155,947 | $156,826 | 28 | $5.5M | Research |
| Therapeutic Learning Center, INC | Health Care and Social Assistance | $120,172 | $121,074 | 9 | <$5M | Research |