| University of Maine Foundation | Other Services (except Public Administration) | $718,600 | $723,311 | 38 | N/A |  Research |
| Independence Advocates of Maine, Inc. | Health Care and Social Assistance | $656,300 | $661,751 | 51 | N/A | Research |
| Penobscot Valley Dermatology | Health Care and Social Assistance | $375,900 | $378,485 | 43 | $13.5M | Research |
| The Housing Foundation Management & Development II | Real Estate and Rental and Leasing | $325,300 | $326,990 | 41 | N/A | Research |
| Cerahelix INC | Manufacturing | $239,500 | $240,957 | 20 | $5.6M | Research |
| Camrep INC | Arts, Entertainment, and Recreation | $225,000 | $226,153 | 77 | $12.6M | Research |
| Black Bear Inn and Conference Center INC | Accommodation and Food Services | $220,087 | $222,123 | 14 | <$5M | Research |
| Woodman's LLC | Accommodation and Food Services | $204,400 | $206,535 | 20 | <$5M | Research |
| Camrep, Inc. | Information | $203,656 | $205,603 | 94 | $15.8M | Research |
| One Stop Home Repair Inc. | Construction | $192,651 | $193,501 | 25 | $7.6M | Research |
| Orono House of Pizza, Inc. | Accommodation and Food Services | $176,659 | $177,341 | 60 | $10.7M | Research |
| Coursestorm Inc. | Information | $173,857 | $175,162 | 16 | <$5M | Research |
| Farnsworth Enterprises INC | Accommodation and Food Services | $171,600 | $173,817 | 48 | $8.5M | Research |
| One Stop Home Rep | Retail Trade | $156,900 | $157,813 | 19 | $6.4M | Research |
| Woodman's Brewing Company LLC | Accommodation and Food Services | $155,900 | $156,766 | 23 | <$5M | Research |
| Harvest Moon Holdings LLC | Accommodation and Food Services | $152,500 | $153,508 | 35 | $6.2M | Research |
| Black Bear Inn and Conference Center | Accommodation and Food Services | $152,500 | $153,631 | 14 | <$5M | Research |
| Sensor Research and Development Corporation | Mining, Quarrying, and Oil and Gas Extraction | $152,000 | $152,933 | 7 | <$5M | Research |
| Farnsworth Enterprises INC | Accommodation and Food Services | $148,750 | $150,176 | 20 | <$5M | Research |
| University Inn Academic Suites LLC | Accommodation and Food Services | $146,048 | $147,261 | 14 | <$5M | Research |
| Woodman's, LLC | Manufacturing | $146,000 | $147,054 | 39 | $13.8M | Research |
| Coursestorm, Inc. | Professional, Scientific, and Technical Services | $144,700 | $145,529 | 13 | <$5M | Research |
| Sensor Research and Development Corporation | Manufacturing | $129,475 | $130,076 | 7 | <$5M | Research |
| Margs Mex Orono LLC | Accommodation and Food Services | $125,677 | $127,500 | 28 | <$5M | Research |
| General Alumni Association of the University of Maine | Other Services (except Public Administration) | $123,000 | $123,967 | 9 | N/A | Research |