| Aroostook County Action Program | Health Care and Social Assistance | $1,546,929 | $1,564,890 | 152 | $24.6M |  Research |
| Falcon Transportation LLC | Transportation and Warehousing | $1,125,745 | $1,087,944 | 79 | $15.9M | Research |
| Lionel Theriault. Inc. | Real Estate and Rental and Leasing | $1,013,290 | $961,608 | 74 | $11.1M | Research |
| Smith's Farm, INC | Agriculture, Forestry, Fishing and Hunting | $696,600 | $700,875 | 135 | $13.8M | Research |
| Smith's Farm, INC | Agriculture, Forestry, Fishing and Hunting | $672,500 | $677,696 | 124 | $12.7M | Research |
| Northeast Packaging Co. | Manufacturing | $650,000 | $658,468 | 87 | $86.3M | Research |
| Personal Services of Aroostook | Health Care and Social Assistance | $467,090 | $468,543 | 75 | $12.8M | Research |
| Aroostook Agency On Aging | Health Care and Social Assistance | $448,800 | $451,804 | 146 | N/A | Research |
| Graves Supermarkets INC | Retail Trade | $393,265 | $397,853 | 20 | <$5M | Research |
| Aroostook Trusses, Inc. | Manufacturing | $367,000 | $370,328 | 39 | $38.7M | Research |
| Life by Design PA | Health Care and Social Assistance | $336,986 | $324,654 | 33 | $7.7M | Research |
| Nor'easter, Inc. | Accommodation and Food Services | $313,782 | $316,012 | 43 | $7.6M | Research |
| Nca INC | Retail Trade | $300,550 | $238,871 | 27 | $6.8M | Research |
| Carrolls Auto Sales INC | Retail Trade | $280,500 | $282,783 | 26 | $6.6M | Research |
| Central Aroostook Association | Health Care and Social Assistance | $276,600 | $453,392 | 63 | N/A | Research |
| Troyco, LLC | Accommodation and Food Services | $270,916 | $272,542 | 69 | $12.3M | Research |
| Currier & Trask, P.a. | Professional, Scientific, and Technical Services | $270,600 | $272,374 | 20 | <$5M | Research |
| Maine Potato Growers INC | Other Services (except Public Administration) | $251,500 | $253,154 | 30 | $6.4M | Research |
| Northern Maine Oral & Facial Surgery, PC | Health Care and Social Assistance | $247,600 | $201,310 | 18 | <$5M | Research |
| Leisure Garden, Inc. | Health Care and Social Assistance | $225,700 | $228,791 | 36 | $6.1M | Research |
| Smith Packing, INC | Agriculture, Forestry, Fishing and Hunting | $225,200 | $226,582 | 12 | <$5M | Research |
| Nor'easter, Inc. | Accommodation and Food Services | $224,000 | $225,394 | 50 | $8.9M | Research |
| Presque Isle Hotel Company | Accommodation and Food Services | $203,000 | $178,978 | 25 | $7.8M | Research |
| Aroostook Regional Transportation System Inc. | Transportation and Warehousing | $202,476 | $203,224 | 18 | $6.9M | Research |
| Presque Isle Animal Hospital PA | Professional, Scientific, and Technical Services | $199,818 | $201,225 | 24 | <$5M | Research |