| Latham Centers, Inc. | Health Care and Social Assistance | $3,084,820 | $1,220,213 | 280 | $47.6M |  Research |
| Pleasant Bay at Brewster Rehab Center LLC | Health Care and Social Assistance | $1,274,910 | $1,287,765 | 124 | $21.1M | Research |
| Maplewood Brewster, LLC | Health Care and Social Assistance | $815,325 | $825,667 | 103 | $17.5M | Research |
| Cape Cod Ready Mix, Inc. | Manufacturing | $673,095 | $678,349 | 36 | $35.7M | Research |
| Specialty Builders' Supply, Inc. | Wholesale Trade | $600,000 | $574,257 | 40 | $12.3M | Research |
| Cape Cod Sea Camps INC | Accommodation and Food Services | $537,299 | $520,497 | 21 | $6.6M | Research |
| Brewster Medical Associates PC | Health Care and Social Assistance | $406,000 | $409,699 | 25 | $7.8M | Research |
| Pleasant Bay at Brewster Assisted Living LLC | Health Care and Social Assistance | $315,255 | $318,434 | 42 | $7.1M | Research |
| Cape Cod National Golf Club, L.l.c. | Arts, Entertainment, and Recreation | $303,750 | $305,902 | 22 | <$5M | Research |
| The Family Schools, Inc. | Health Care and Social Assistance | $276,000 | $280,117 | 114 | $18.5M | Research |
| Eric Meads, Inc. | Construction | $266,765 | $269,559 | 16 | $5.5M | Research |
| Benger Construction, LLC | Construction | $259,500 | $261,185 | 17 | $5.2M | Research |
| The Family Schools Inc. | Health Care and Social Assistance | $251,785 | $254,191 | 20 | <$5M | Research |
| Cape Sand & Recycling LLC | Mining, Quarrying, and Oil and Gas Extraction | $250,000 | $252,972 | 16 | <$5M | Research |
| The Compact of Cape Cod Conservation Trusts Inc. | Other Services (except Public Administration) | $212,005 | $213,931 | 20 | N/A | Research |
| The Compact of Cape Cod Conservation Trusts, Inc. | Real Estate and Rental and Leasing | $210,115 | $211,545 | 18 | N/A | Research |
| Paraclete Press Inc. | Information | $178,385 | $180,050 | 31 | $5.2M | Research |
| Paraclete Press, Inc. | Manufacturing | $178,384 | $179,915 | 31 | $30.7M | Research |
| Snowy Owl Coffee Roasters LLC | Accommodation and Food Services | $176,008 | $177,607 | 18 | <$5M | Research |
| Brewster Veterinary Hospital Corp | Professional, Scientific, and Technical Services | $166,600 | $168,669 | 21 | <$5M | Research |
| The Laurel Education Center INC | Educational Services | $160,500 | $146,690 | 27 | <$5M | Research |
| Cape Dreams Building and Design LLC | Construction | $148,800 | $149,887 | 10 | <$5M | Research |
| Tom Turcketta Inc. | Construction | $148,468 | $150,047 | 12 | <$5M | Research |
| Brewster Baptist Church | Other Services (except Public Administration) | $145,000 | $146,293 | 12 | N/A | Research |
| Brewster Fish House LLC | Accommodation and Food Services | $143,083 | $144,259 | 15 | <$5M | Research |