| Allergy and Immunology Associates of New England, LLC | Health Care and Social Assistance | $693,749 | $697,331 | 57 | $17.9M |  Research |
| Florence Casket Co | Manufacturing | $605,000 | $608,531 | 51 | $14.2M | Research |
| Highland Valley Elder Services Inc. | Health Care and Social Assistance | $583,200 | $586,316 | 87 | $14.1M | Research |
| Represent.us Education Fund | Educational Services | $522,383 | $531,399 | 41 | N/A | Research |
| Hampshire Gastroenterology Associates | Health Care and Social Assistance | $413,700 | $418,274 | 29 | $9.1M | Research |
| Eye Physicians of Northampton, PC | Health Care and Social Assistance | $405,800 | $402,009 | 27 | $6.3M | Research |
| Eye Physicians of Northampton PC | Health Care and Social Assistance | $399,612 | $402,875 | 27 | $8.5M | Research |
| Cooper's Dairyland of Northampton INC | Retail Trade | $382,578 | $384,748 | 87 | $21.7M | Research |
| Hampshire Gastroenterology Associates | Health Care and Social Assistance | $378,275 | $380,345 | 25 | $7.8M | Research |
| Frank Newhall Look Memorial Park INC | Arts, Entertainment, and Recreation | $345,872 | $347,919 | 25 | N/A | Research |
| Keiter Corporation | Construction | $307,000 | $310,095 | 37 | $42.2M | Research |
| Bi-Qem INC | Manufacturing | $279,659 | $282,662 | 27 | $26.8M | Research |
| Molding Business Services, INC | Professional, Scientific, and Technical Services | $259,678 | $261,677 | 11 | <$5M | Research |
| Valley Home Improvement, Inc. | Construction | $227,829 | $231,287 | 20 | $6.1M | Research |
| Northampton Veterinary Clinic LLC | Professional, Scientific, and Technical Services | $226,000 | $227,115 | 28 | <$5M | Research |
| Florence Dental Care | Health Care and Social Assistance | $213,584 | $216,884 | 17 | <$5M | Research |
| Frank Newhall Look Memorial Park | Arts, Entertainment, and Recreation | $213,400 | $214,581 | 104 | N/A | Research |
| Rigali & Walder | Health Care and Social Assistance | $205,000 | $206,404 | 24 | $5.6M | Research |
| Rigali & Walder Orthodontics PC | Health Care and Social Assistance | $205,000 | $205,938 | 19 | <$5M | Research |
| Systemone, LLC | Information | $200,197 | $202,883 | 8 | <$5M | Research |
| Salmon Studios LLC | Manufacturing | $195,000 | $196,619 | 19 | <$5M | Research |
| Balin Eye and Laser Center | Health Care and Social Assistance | $191,000 | $192,565 | 16 | $5.0M | Research |
| Nancy Balin | Health Care and Social Assistance | $182,298 | $183,028 | 16 | $5.0M | Research |
| Florence Dental Care | Health Care and Social Assistance | $180,582 | $182,553 | 13 | <$5M | Research |
| Classic Colonial Homes, Inc. | Construction | $170,228 | $171,142 | 14 | <$5M | Research |