| Hyannis Air Service INC | Transportation and Warehousing | $8,134,253 | $8,201,696 | 500 | $126.8M |  Research |
| Sencorpwhite, Inc. | Manufacturing | $4,740,632 | $4,795,281 | 230 | $60.2M | Research |
| 886 Ventures, LLC | Information | $4,000,000 | $4,053,333 | 170 | $28.5M | Research |
| Catania Hospitality Group, INC | Management of Companies and Enterprises | $2,845,677 | $2,878,639 | 432 | $71.0M | Research |
| Hyannis Harbor Tours INC | Transportation and Warehousing | $2,760,640 | $2,798,059 | 196 | $49.7M | Research |
| Shepley Wood Products, INC | Wholesale Trade | $2,541,900 | $2,570,849 | 155 | $47.5M | Research |
| Cape Abilities | Health Care and Social Assistance | $2,338,500 | $2,371,629 | 400 | N/A | Research |
| Hyannis Harbor Tours INC | Transportation and Warehousing | $2,000,000 | $2,044,111 | 114 | $28.9M | Research |
| Sencorpwhite INC | Manufacturing | $2,000,000 | $2,018,222 | 240 | $62.8M | Research |
| Catania Hospitality Group INC | Accommodation and Food Services | $2,000,000 | $2,014,667 | 307 | $96.0M | Research |
| Xiphias Enterprises INC | Retail Trade | $1,347,412 | $1,286,238 | 87 | $21.9M | Research |
| Cape Cod Orthopedics & Sports Medicine PC | Health Care and Social Assistance | $1,289,845 | $1,297,297 | 94 | $29.5M | Research |
| Housing Assistance Corporation | Health Care and Social Assistance | $1,268,900 | $1,277,606 | 109 | N/A | Research |
| Living Independently Forever, Inc. | Health Care and Social Assistance | $1,239,525 | $1,254,021 | 175 | $29.8M | Research |
| Cape Cod Orthopedics and Sports Medicine PC | Health Care and Social Assistance | $1,219,900 | $1,227,680 | 67 | $21.0M | Research |
| Duffy Community Health Center | Health Care and Social Assistance | $1,205,315 | $1,208,165 | 90 | N/A | Research |
| Essex Pavilion, LLC | Health Care and Social Assistance | $1,156,000 | $1,168,202 | 84 | $14.3M | Research |
| Pain D'avignon II INC | Manufacturing | $1,069,737 | $1,078,060 | 110 | $38.8M | Research |
| Warren T. Baxter INC | Accommodation and Food Services | $991,334 | $998,741 | 49 | $8.7M | Research |
| Innseason Management INC | Accommodation and Food Services | $947,837 | $961,263 | 89 | $27.8M | Research |
| Pain D'avignon II INC | Manufacturing | $924,700 | $932,858 | 110 | $38.8M | Research |
| Williams Building Company INC | Construction | $882,721 | $890,371 | 44 | $50.1M | Research |
| Williams Building Company INC | Construction | $871,400 | $882,656 | 44 | $13.4M | Research |
| Spankys Clam Shack LLC | Accommodation and Food Services | $856,474 | $867,608 | 20 | <$5M | Research |
| Hyannis Marina INC | Accommodation and Food Services | $777,737 | $783,916 | 56 | $17.5M | Research |