| Talentburst, Inc. | Administrative and Support and Waste Management | $6,756,700 | $6,853,734 | 490 | $77.1M |  Research |
| Hyde Park Burgers, LLC | Accommodation and Food Services | $2,482,900 | $2,510,586 | 479 | $85.0M | Research |
| Nic & Zoe Company | Wholesale Trade | $2,396,617 | $2,433,518 | 163 | $49.9M | Research |
| Bahwan Cybertek INC | Professional, Scientific, and Technical Services | $2,234,515 | $2,259,309 | 106 | $21.9M | Research |
| Talentburst Payroll, Inc. | Administrative and Support and Waste Management | $2,185,800 | $2,214,701 | 278 | $43.8M | Research |
| Herb Chambers of Natick INC | Retail Trade | $2,044,830 | $2,068,360 | 143 | $36.0M | Research |
| Nic & Zoe Company | Wholesale Trade | $2,000,000 | $2,059,507 | 120 | $30.9M | Research |
| Accept Education Collaborative Corporation | Educational Services | $1,912,784 | $1,930,602 | 245 | N/A | Research |
| Centage Corporation | Information | $1,796,212 | $1,817,068 | 83 | $13.9M | Research |
| Care Everywhere LLC | Professional, Scientific, and Technical Services | $1,723,010 | $1,738,635 | 90 | $18.6M | Research |
| Brandon Residential Treatment Center, Inc. | Educational Services | $1,714,092 | $1,726,138 | 200 | N/A | Research |
| Scrub-A-Dub Auto Wash Ctrs INC | Other Services (except Public Administration) | $1,661,260 | $1,673,776 | 235 | $46.1M | Research |
| Walnut Hill School for the Arts | Educational Services | $1,604,200 | $1,615,847 | 153 | N/A | Research |
| Ddh Hotel Natick/worcester LLC | Accommodation and Food Services | $1,421,103 | $806,169 | 103 | $32.2M | Research |
| Ernest Guigli & Sons Inc. | Construction | $1,418,366 | $1,429,083 | 48 | $18.0M | Research |
| Ernest Guigli & Sons, Inc. | Construction | $1,418,365 | $1,427,004 | 80 | $30.0M | Research |
| Brigham Gill Motorcars INC | Retail Trade | $1,326,540 | $1,342,862 | 69 | $17.4M | Research |
| Orthopedics New England Inc. | Health Care and Social Assistance | $1,207,415 | $1,220,018 | 63 | $19.8M | Research |
| Orthopedics New England INC | Health Care and Social Assistance | $1,207,415 | $1,219,919 | 64 | $20.1M | Research |
| Weruva International, INC | Wholesale Trade | $1,195,600 | $1,087,911 | 67 | $17.2M | Research |
| Allurion Technologies, Inc. | Other Services (except Public Administration) | $1,117,500 | $1,023,870 | 70 | $13.4M | Research |
| Delsys Inc. | Manufacturing | $1,065,100 | $585,576 | 31 | $30.7M | Research |
| Ddh Hotel Natick Worcester, LLC | Accommodation and Food Services | $1,028,501 | $752,143 | 119 | $37.2M | Research |
| Allurion Technologies Inc. | Other Services (except Public Administration) | $1,015,800 | $1,019,694 | 50 | $9.6M | Research |
| Busek Co., Inc. | Professional, Scientific, and Technical Services | $976,857 | $987,188 | 49 | $10.2M | Research |