| Cadillac Casting, INC | Manufacturing | $5,882,925 | $5,950,619 | 415 | $108.7M |  Research |
| Zhongding USA Cadillac INC | Manufacturing | $1,943,467 | $1,964,791 | 221 | $78.0M | Research |
| Heritage Broadcasting Company of Michigan | Information | $1,699,078 | $1,710,499 | 125 | $21.0M | Research |
| Brooks & Perkins, Inc. | Manufacturing | $812,032 | $816,904 | 68 | $16.6M | Research |
| Van Drie Furniture Company of Cadillac, Inc. | Retail Trade | $615,616 | $619,394 | 74 | $13.4M | Research |
| Don's Auto Clinic INC | Retail Trade | $614,020 | $618,041 | 50 | $12.6M | Research |
| Inland Lakes Machine Inc. | Manufacturing | $597,198 | $601,743 | 39 | $9.5M | Research |
| Inland Lakes Machine INC | Manufacturing | $597,198 | $603,366 | 39 | $10.9M | Research |
| Highpoint Auto & Truck Center INC | Management of Companies and Enterprises | $568,390 | $572,112 | 46 | $7.6M | Research |
| Caberfae Management Corporation | Accommodation and Food Services | $542,500 | $545,502 | 200 | $62.5M | Research |
| Baird, Cotter and Bishop, P.c. | Professional, Scientific, and Technical Services | $473,900 | $476,678 | 37 | $11.8M | Research |
| Cadillac Family Physicians, P.c. | Health Care and Social Assistance | $470,000 | $473,969 | 51 | $16.0M | Research |
| Betten Baker Cadillac Michigan, Inc. | Retail Trade | $460,615 | $466,759 | 44 | $11.1M | Research |
| Mcguires Evergreen Golf Course | Accommodation and Food Services | $458,251 | $462,082 | 65 | $20.3M | Research |
| Dental Health Professionals P.c. | Health Care and Social Assistance | $412,373 | $413,909 | 50 | $11.6M | Research |
| Dental Health Professionals, P.c. | Health Care and Social Assistance | $412,372 | $415,465 | 53 | $12.3M | Research |
| Caberfae Management Corporation | Arts, Entertainment, and Recreation | $387,500 | $389,373 | 200 | $28.0M | Research |
| Family Practice of Cadillac PC | Health Care and Social Assistance | $387,333 | $391,461 | 36 | $11.3M | Research |
| Spencer Plastics, Inc. | Manufacturing | $386,504 | $389,745 | 37 | $36.7M | Research |
| Spencer Plastics Inc. | Manufacturing | $386,504 | $388,675 | 37 | $36.7M | Research |
| Metal Punch Corp | Manufacturing | $357,700 | $362,529 | 28 | $7.3M | Research |
| Network Reporting Corporation | Professional, Scientific, and Technical Services | $353,522 | $355,566 | 49 | $6.9M | Research |
| Network Reporting Corporation | Professional, Scientific, and Technical Services | $353,522 | $356,166 | 47 | $6.6M | Research |
| Dynamic Physical Therapy P.c. | Health Care and Social Assistance | $352,685 | $355,294 | 29 | $7.8M | Research |
| Dynamic Physical Therapy, Inc. | Health Care and Social Assistance | $352,685 | $355,313 | 29 | $7.8M | Research |