| University Liggett School | Educational Services | $2,032,022 | $1,742,367 | 179 | N/A |  Research |
| Abbott Nicholson PC | Professional, Scientific, and Technical Services | $675,330 | $682,749 | 49 | $11.9M | Research |
| The Grosse Pointe-Academy | Educational Services | $532,530 | $536,732 | 50 | N/A | Research |
| Lucia Landscaping Inc. | Administrative and Support and Waste Management | $460,700 | $464,007 | 50 | $10.8M | Research |
| Village Quality Market | Retail Trade | $396,100 | $399,453 | 70 | $17.5M | Research |
| Donnelly Penman & Partners | Finance and Insurance | $323,700 | $325,598 | 14 | $7.2M | Research |
| Nabro, Inc. | Retail Trade | $323,415 | $326,711 | 57 | $14.2M | Research |
| Metropolitan Orthopaedic Associates | Health Care and Social Assistance | $323,200 | $146,454 | 13 | <$5M | Research |
| Anchor Bay Clinic Family Medical | Health Care and Social Assistance | $282,500 | $285,542 | 35 | $11.0M | Research |
| Kbdetroit, LLC | Wholesale Trade | $276,900 | $279,070 | 31 | $8.0M | Research |
| Markam Transport, INC | Manufacturing | $274,883 | $278,994 | 18 | <$5M | Research |
| Prm Holdings LLC DBA Hope Senior Home Care | Health Care and Social Assistance | $248,112 | $249,321 | 41 | $7.0M | Research |
| Grace Community Church | Other Services (except Public Administration) | $245,182 | $246,517 | 35 | N/A | Research |
| Lupo & Koczkur P.c. | Professional, Scientific, and Technical Services | $244,300 | $246,683 | 17 | <$5M | Research |
| Lupo & Koczkur PC | Professional, Scientific, and Technical Services | $244,300 | $245,846 | 17 | <$5M | Research |
| Prm Holdings LLC DBA Hope Senior Home Care | Health Care and Social Assistance | $234,815 | $237,033 | 48 | $8.2M | Research |
| Macomb Anesthesia PC | Health Care and Social Assistance | $229,168 | $232,081 | 11 | <$5M | Research |
| Neighborhood Club | Arts, Entertainment, and Recreation | $221,942 | $210,170 | 36 | N/A | Research |
| Neighborhood Club | Other Services (except Public Administration) | $208,610 | $209,422 | 36 | N/A | Research |
| Demand Telemarketing, Inc. | Administrative and Support and Waste Management | $192,100 | $194,309 | 12 | <$5M | Research |
| Rc Acquisition LLC | Management of Companies and Enterprises | $185,046 | $187,121 | 36 | $5.9M | Research |
| Dirty Dog Jazz Cafe, LLC | Accommodation and Food Services | $179,410 | $180,476 | 40 | $7.1M | Research |
| Grosse Pointe Dermatology Associates P. C. | Health Care and Social Assistance | $176,162 | $177,943 | 19 | $6.0M | Research |
| Grosse Pointe Dermatology Associates, P. C. | Health Care and Social Assistance | $176,162 | $177,538 | 18 | $5.6M | Research |
| Camp Quality USA Inc. | Accommodation and Food Services | $162,921 | $164,125 | 21 | N/A | Research |