| Northern Michigan Rehabilitation Services Inc. | Health Care and Social Assistance | $481,513 | $485,958 | 55 | $14.8M |  Research |
| American Spoon Foods, Inc. | Manufacturing | $450,028 | $453,003 | 50 | $17.6M | Research |
| Harbor Hall, Inc. | Health Care and Social Assistance | $448,370 | $451,372 | 50 | N/A | Research |
| Meyer True Value Hardware Co. | Retail Trade | $402,433 | $406,093 | 70 | $14.5M | Research |
| Mitchell Graphics INC | Manufacturing | $401,072 | $403,490 | 38 | $37.7M | Research |
| Mitchell Graphics INC | Manufacturing | $401,072 | $404,782 | 34 | $33.7M | Research |
| Marco LLC | Administrative and Support and Waste Management | $392,180 | $393,346 | 48 | $10.4M | Research |
| Marco, LLC | Administrative and Support and Waste Management | $392,180 | $396,243 | 48 | $10.4M | Research |
| Women's Resource Center of Northern Michigan | Health Care and Social Assistance | $382,500 | $385,592 | 26 | N/A | Research |
| Bay Area Management Services | Health Care and Social Assistance | $375,268 | $377,170 | 53 | $16.6M | Research |
| Petoskey Surgeons, P.c. | Health Care and Social Assistance | $374,231 | $378,230 | 31 | $9.7M | Research |
| Beards Brewery, LLC | Accommodation and Food Services | $371,112 | $373,009 | 42 | $7.5M | Research |
| Grain Train Natural Food Co-Operative, I Nc. | Retail Trade | $353,510 | $357,321 | 63 | $11.0M | Research |
| Zd Metal Products, Inc. | Other Services (except Public Administration) | $347,180 | $348,848 | 33 | $6.3M | Research |
| St. Francis Xavier Church | Other Services (except Public Administration) | $346,705 | $348,882 | 43 | N/A | Research |
| Northern Imaging Associates P.c. | Health Care and Social Assistance | $345,732 | $349,587 | 11 | <$5M | Research |
| Centerfor Pulmonary and Sleep Medicine PC | Health Care and Social Assistance | $334,091 | $336,829 | 28 | <$5M | Research |
| Walloon Lake Country Club | Arts, Entertainment, and Recreation | $313,902 | $316,387 | 46 | $6.4M | Research |
| Klepadlo Winnell Nuorala PC | Professional, Scientific, and Technical Services | $310,673 | $313,354 | 19 | $6.0M | Research |
| Northern Brewing LLC | Accommodation and Food Services | $306,062 | $308,335 | 40 | $7.1M | Research |
| Quick Care Family Medical Center, P.c. | Health Care and Social Assistance | $290,133 | $292,308 | 27 | $8.5M | Research |
| Petoskey Brewing Company LLC | Accommodation and Food Services | $285,337 | $287,041 | 25 | <$5M | Research |
| Petoskey Ear, Nose & Throat Specialists, P.l.l.c. | Health Care and Social Assistance | $275,040 | $277,317 | 23 | $7.2M | Research |
| Bayview Ob/gyn, P.c. | Health Care and Social Assistance | $259,380 | $261,844 | 24 | $7.5M | Research |
| Common Angle, Inc. | Administrative and Support and Waste Management | $256,400 | $257,668 | 22 | <$5M | Research |