| Goodwill Industries of St Clair County | Health Care and Social Assistance | $362,519 | $365,359 | 134 | $21.7M | AI Deep Dive |
| Marwan Shuayto MD P.c. | Health Care and Social Assistance | $356,697 | $358,940 | 40 | $12.6M | AI Deep Dive |
| Ainsworth Electric Inc. | Construction | $352,000 | $355,800 | 29 | $9.5M | AI Deep Dive |
| O.e.m. Company Inc. | Manufacturing | $350,422 | $354,371 | 50 | $13.1M | AI Deep Dive |
| O.e.m. Company, Inc. | Manufacturing | $348,905 | $352,096 | 36 | $9.4M | AI Deep Dive |
| St. Clair Medical PC | Health Care and Social Assistance | $345,000 | $347,080 | 31 | $9.7M | AI Deep Dive |
| Cipa Usa, Inc. | Wholesale Trade | $329,800 | $332,456 | 33 | $10.1M | AI Deep Dive |
| Cipa USA Inc. | Wholesale Trade | $329,800 | $332,113 | 29 | $8.9M | AI Deep Dive |
| Ainsworth Electric INC | Construction | $329,600 | $332,879 | 20 | $6.6M | AI Deep Dive |
| X-Ray Associates of Port Huron P.c. | Health Care and Social Assistance | $320,400 | $323,744 | 9 | <$5M | AI Deep Dive |
| Port Huron Internal Medicine Associates, P.c. | Health Care and Social Assistance | $317,595 | $319,817 | 30 | $9.4M | AI Deep Dive |
| Port Huron Internal Medicine Associates P.c. | Health Care and Social Assistance | $317,595 | $320,111 | 29 | $9.1M | AI Deep Dive |
| Liggett Communications LLC | Arts, Entertainment, and Recreation | $314,063 | $316,252 | 21 | <$5M | AI Deep Dive |
| Huron Surgical | Health Care and Social Assistance | $312,500 | $110,499 | 6 | <$5M | AI Deep Dive |
| Sperry's Theatre Operations LLC | Arts, Entertainment, and Recreation | $310,253 | $214,378 | 85 | $13.9M | AI Deep Dive |
| Dyck Security Services Inc. | Administrative and Support and Waste Management | $299,400 | $302,279 | 41 | $6.0M | AI Deep Dive |
| Timetrak Systems Inc. | Professional, Scientific, and Technical Services | $296,643 | $298,373 | 20 | <$5M | AI Deep Dive |
| Huron Medical Center P.c. | Health Care and Social Assistance | $295,675 | $298,826 | 24 | $7.5M | AI Deep Dive |
| Auto Anodics, Inc. | Manufacturing | $294,937 | $297,538 | 24 | $5.9M | AI Deep Dive |
| Auto Anodics Inc. | Manufacturing | $294,935 | $296,982 | 24 | $5.9M | AI Deep Dive |
| Port Huron E.n.t., P.c. | Health Care and Social Assistance | $294,670 | $296,396 | 16 | $5.0M | AI Deep Dive |
| Oldford & Associates Inc. | Administrative and Support and Waste Management | $294,600 | $297,078 | 12 | <$5M | AI Deep Dive |
| Vincent's Heating and Plumbing, Inc. | Construction | $290,300 | $292,718 | 19 | $6.0M | AI Deep Dive |
| Lawrence H Beck DDS PC | Health Care and Social Assistance | $290,200 | $292,212 | 24 | $5.6M | AI Deep Dive |
| Precision Computer Solutions, Inc. | Professional, Scientific, and Technical Services | $285,700 | $288,111 | 16 | <$5M | AI Deep Dive |