| Michigan Institute of Urology | Health Care and Social Assistance | $5,397,300 | $5,468,964 | 499 | $156.6M |  Research |
| Yates Industries Inc. | Manufacturing | $2,247,700 | $2,275,234 | 186 | $48.7M | Research |
| Genesis Automotive Group Inc. | Retail Trade | $1,603,310 | $1,616,488 | 139 | $35.0M | Research |
| Shores Rheumatology PC | Health Care and Social Assistance | $1,467,600 | $244,885 | 15 | <$5M | Research |
| Eastlake Cardiovascular PC | Health Care and Social Assistance | $1,438,800 | $1,447,793 | 103 | $32.3M | Research |
| Eastlake Cardiovascular PC | Health Care and Social Assistance | $1,438,800 | $1,449,311 | 103 | $32.3M | Research |
| Roy O'brien, INC | Retail Trade | $1,409,800 | $1,419,120 | 105 | $26.5M | Research |
| Michigan Neurology Associates P.c. | Health Care and Social Assistance | $1,096,385 | $1,103,906 | 124 | $38.9M | Research |
| St. Clair Orthopaedics & Sports Medicine, P.c. | Health Care and Social Assistance | $1,029,700 | $1,037,938 | 104 | $32.6M | Research |
| Viviano Flower Shop INC | Retail Trade | $754,000 | $759,718 | 144 | $27.3M | Research |
| Viviano Flower Shop INC | Retail Trade | $728,832 | $734,096 | 153 | $29.0M | Research |
| Caribbean Dream LLC | Accommodation and Food Services | $609,095 | $548,423 | 74 | $13.1M | Research |
| Capas Inc. | Professional, Scientific, and Technical Services | $608,700 | $611,997 | 29 | <$5M | Research |
| Lakeshore Ear, Nose and Throat Center P.c. | Health Care and Social Assistance | $583,100 | $589,968 | 21 | $6.6M | Research |
| Pretige Authhaus INC | Retail Trade | $558,442 | $565,693 | 48 | $12.1M | Research |
| Associated Orthopedists of Detroit P.c. | Retail Trade | $558,200 | $564,681 | 75 | $13.1M | Research |
| Surgicalone, Inc. | Wholesale Trade | $537,842 | $541,502 | 310 | $95.0M | Research |
| Jefferson Beach Yacht Sales Inc. | Retail Trade | $535,887 | $539,207 | 42 | $11.0M | Research |
| Colony Marine Sales and Service Inc. | Retail Trade | $529,862 | $533,939 | 59 | $15.4M | Research |
| Prestige Autohaus Inc. | Retail Trade | $528,802 | $532,689 | 55 | $13.9M | Research |
| Brownie's On the Lake LLC | Accommodation and Food Services | $523,600 | $295,109 | 50 | $8.9M | Research |
| Colony Marine Sales and Service, Inc. | Retail Trade | $523,323 | $528,280 | 59 | $15.4M | Research |
| Surgicalone Inc. | Wholesale Trade | $510,427 | $515,137 | 28 | $8.6M | Research |
| Jefferson Beach Yacht Sales, Inc. | Retail Trade | $469,725 | $474,174 | 35 | $9.1M | Research |
| Gtj Consulting L.l.c. | Real Estate and Rental and Leasing | $462,012 | $465,366 | 28 | $5.1M | Research |